The scientists whose research anti-vaxxers use their children should be genetically exempt from vaccines, have now said that their old work is no longer valid.
Anti-vaxxer doctors and even parents have ordered genetic tests from companies like 23andMe looking for a variant of the MTHFR gene in their patients and children.
That's because a 2008 study suggested that people with that variant would be susceptible to & # 39; side effects & # 39; in response to smallpox heads (which are no longer given).
But two of his authors, Dr. James Crowe and Dr. David Reif now say that our understanding of and the methodology for studying DNA have changed so dramatically that their ten-year-old research is no longer valid, they said The Atlantic Ocean.
A decade-old study suggested a link between a gene variant and responses to a smallpox vaccine – which is no longer being used – which anti-vaxxers cite to justify medical exemptions. The authors of the study say that the study & # 39; no longer valid & # 39; is according to current standards (file)
The California law against philosophical exemptions for vaccines was passed in 2016 in the aftermath of a brutal measles outbreak that began in Disneyland.
But that did not prevent vaccinee and anti-vaccinating parents – who were still worried about the now debilitated research that links the BMR vaccine to autism – to find ways to get their children out of the shots.
In the last two years, the number & # 39; medical & # 39; exemptions from shots in California tripled, according to a JAMA report.
And only because it's like & # 39; medical & # 39; has been identified and issued by a doctor, this does not necessarily mean that they are medically valid.
Earlier this month, Dr. Kenneth Stoller in San Francisco was summoned by the city attorney on suspicion that improper vaccine exemptions were issued and benefited from the practice.
According to city lawyer Dennis Herrera has no more than & # 39; two 30-minute visits and a genetic test of 23andMe & # 39; used to determine that children should be exempt from admissions.
Online resources also inform consumers about how to upload raw data from their own DNA tests to look for a variant of a gene called MTHFR (which will detect the genetic profiling of 23andMe, but the company does not test specifically for that), which is linked to & # 39; adverse effects & # 39; of smallpox vaccinations.
But 23andMe itself says that the tests should not be used as a basis for medical decisions.
Smallpox vaccinations are no longer given because the disease is considered eradicated.
And now the scientists who reported the MTHFR vaccine reaction link say that the genetic variant does not do what they thought it did.
In 2008 Dr. Reif, Dr. Crowe and their colleague & # 39; s a study in the Journal of Infectious Disease that MTHFR to & # 39; systemic side effects & # 39; or links reactions to the smallpox vaccine.
Adverse effects were defined for the purposes of the study, such as fever, rash, or swollen lymph nodes (an immune system response) in the area of uptake.
The researchers gave smallpox to more than 130 healthy adults who had never had the vaccine, checked them for any of these symptoms, and then analyzed their genomes.
Those with a certain variant of MTHFR were more likely to experience these non-life threatening reactions.
But in part, the effects were from the smallpox vaccine, which has not been routinely in the US since 1972 and would not necessarily take place with another vaccination.
And when the study came to the fore in a court case from 2016, the authors rated their own methodology as outdated.
& # 39; It's just not a valid study according to today's methodology & # 39 ;, lead research writer Dr. James Crowe, who is now director of the Vanderbilt Vaccincentrum, told The Atlantic.
& # 39; It is not even a valid study according to today's methodology. & # 39;
He added that applying the study findings to the BMR vaccine as a basis for medical exemption & # 39; illogical and inappropriate & # 39; is.
In addition to changing methodologies, we just know much more about genes and the way genetics works than we did ten years ago – including that the MTHFR gene has broad effects.
MTHFR encodes an enzyme key for the body's ability to make proteins.
And about 40 percent of us have the variant that Dr. Crowe and his team originally linked to & # 39; side effects & # 39; of the smallpox vaccine (which is not used and which is not the same as one of the vaccines used today).
No one like this research has made the same waves as the research of dr. Crowe and Dr. Reif in 2008, apparently.
That didn't stop 23andMe customers from asking more about the MTHFR gene than any other.
23andMe, however, wrote a blog post to ease the fears of consumers.
& # 39; Despite a lot of research – and a lot of buzz – existing scientific data does not support the vast majority of claims that ordinary MTHFR variants affect human health & # 39 ;, the company wrote on its blog.
But doctors conspiring with parents to get inappropriate medical exemptions from vaccines for their children still blame genetics.
So Dr. Crowe and his co-authors take matters into their own hands, according to The Atlantic, but write to the Journal of Infectious Diseases and beg it to say that their research doesn't say much.
. (TagsToTranslate) Dailymail (t) health