Distribution and frequency of aminoglycoside-resistant strains. The darker the color, the higher the amount of reports. a) both aminoglycoside modifying (AME) genotypes and 16S rRNA demethylase genotypes; b) AME genotypes; c) 16S rRNA methylase genotypes. credit: Biosafety and health (2023). DOI: 10.1016/j.bsheal.2023.01.001
Choosing the right antibiotics to treat bacterial infections is becoming more difficult due to the emergence of antibiotic-resistant bacteria. Aminoglycosides, as broad-spectrum antibiotics, are increasingly being used clinically; However, for the most effective use of aminoglycosides, a comprehensive understanding of the prevalence and prevalence of aminoglycoside-resistant genes is required.
Therefore, in order to better understand the status of global antibiotic resistance to aminoglycosides and the prevalence of antibiotic resistance genes (ARGs) in various bacterial species, a recent article was published in Biosafety and health It collects relevant data from multiple studies.
Two mechanisms of primary resistance—enzymatic modification of aminoglycosides and 16S rRNA methylation—were evaluated and the corresponding proliferation of ARGs was described. The coexistence of aminoglycoside ARGs with other ARGs has also been demonstrated, as has the relationship between aminoglycoside ARGs and resistant phenotypes.
The lack of effective therapeutic agents to combat resistant pathogens represents a real threat to public health. Combining aminoglycosides with other antibiotics may provide a novel therapeutic strategy.
more information:
Yuan Zhang et al, Prevalence and distribution of aminoglycoside resistance genes, Biosafety and health (2023). DOI: 10.1016/j.bsheal.2023.01.001
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the quote: Prevalence and Distribution of Aminoglycoside Resistance Genes (2023, April 17) Retrieved April 17, 2023 from https://phys.org/news/2023-04-prevalence-aminoglycoside-resistance-genes.html
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