Unai Emery makes two changes from his win against Arsenal, as Matty Cash and Douglas Luiz replace Diego Carlos and Morgan Rogers.
That will see Ezri Konsa return to his natural central position, as opposed to the full-back role he played at the Emirates.
Meanwhile, the locals add Yusuf Yazici to the attack, in the only change after the defeat in the first leg.
Lille XI: Chevalier, Tiago Santos, Diakite, Yoro, Ismaily, Andre, Bentaleb, Yazici, Haraldsson, Gudmundsson, David.
Substitutes: Mannone, Ngrel, Alexsandro, Gomes, Cabella, Ounas, Cavaleiro, Morais, Bouaddi, Touré, Ferrah.
Villa XI: MartÃnez, Cash, Konsa, Pau, Digne, Luiz, Tielemans, Diaby, Zaniolo, McGinn, Watkins.
Substitutes: Olsen, Gauci, Carlos, Lenglet, Durán, Rogers, Kelser-Hayden, Bailey, Iroegbunam, Munroe, Kellyman.
- Why has Pep Guardiola appeared on stage with Noel Gallagher? The Man City boss was spotted behind the rock star at a charity concert at the Royal Albert Hall last night, but the former Oasis songwriter can explain!
- THE EURO FILES: Draw opens up for Diego Simeone’s Atletico Madrid eight years after European final heartbreak, it could be Kylian Mbappe’s time to shine and Barcelona’s talent factory is still going strong
- Bianca Bustamante, 19, burst onto the scene with two wins during the inaugural F1 Academy season, now she’s been snapped by McLaren as a development driver… and has more than two MILLION followers
- Footy legend Wally Lewis opens up about the terrible toll head knocks have taken on him – and the unimaginable tragedy that forced him to seek help