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Update on Golden Retriever Lifetime Study published

golden retriever

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As the Morris Animal Foundation Golden Retriever Lifetime Study approaches its 10th anniversary, a newly published article in the magazine PLOS ONE summarizes the findings of the investigation to date and provides a preview of the ongoing investigation.

The research team’s latest publication summarizes the cohort’s current demographics, as well as reports on health parameters such as cancer diagnoses and deaths.

“The new publication provides detailed information about our cohort as of May 2021,” said Dr. Julia Labadie, former epidemiologist on the study, currently Senior Scientist, Statistical Genetics at Wisdom Health, and lead author of the paper. “We hope the article will not only inform the veterinary and lay community about the study, but will encourage more researchers to contact us for access to samples and data.”

The paper provides an update on the primary endpoints, as of May 31, 2021, tracking the occurrence of the four major cancers of interest: hemangiosarcoma, lymphoma/leukemia, osteosarcoma, and high-grade mast cell tumors. At that point, the study had obtained 223 of the 500 desired primary endpoints, with hemangiosarcoma being the most common. The current paper also reports on some of the challenges the research is addressing, including assessing veterinary diagnoses.

Other important findings and publications of the research to date include biochemical variation in healthy dogs, factors associated with early adherence, age at gonadectomy and risk of orthopedic injury and overweight/obesity, and inbreeding depression.

More than 3,000 golden retrievers from the contiguous United States originally participated in the study, which began in 2012 and was fully enrolled in 2015. Owners and veterinarians fill out annual online questionnaires about the health status and lifestyle of the dogs. Biological samples are also collected and each dog is physically examined annually.

The Golden Retriever Lifetime Study is the most comprehensive prospective study ever conducted in veterinary medicine, collecting information on enrolled golden retrievers throughout their lives to determine nutritional, environmental, lifestyle, and genetic risk factors for cancer and other diseases. to identify in dogs. It is the first Morris Animal Foundation-funded study conceived, designed and conducted by the Foundation and its scientific team.

“The Golden Retriever Lifetime Study is a rich source of data and samples from the first longitudinal cohort of dogs of this size,” said Dr. Janet Patterson-Kane, Chief Scientific Officer of the Morris Animal Foundation and another author of the article. “The research data and samples are a legacy of these special dogs, which will continue to influence scientific discoveries for decades to come.”


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More information:
Julia Labadie et al, Cohort Profile: The Golden Retriever Lifetime Study (GRLS), PLOS ONE (2022). DOI: 10.1371/journal.pone.0269425

Provided by Morris Animal Foundation

Quote: Update on Golden Retriever Lifetime Study published (2022, June 14) retrieved June 14, 2022 from https://phys.org/news/2022-06-golden-lifetime-published.html

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