A study revealed that a jab that destroys skin cancer and stops it may be one step closer.
Scientists have created a cocktail of drugs that can fight deadly melanoma with a 100 percent success rate in mice.
They simply added a known chemical to stimulate the immune system to a drug that is already being tested for cancer therapy.
Within 54 days, a single type of cancer killed 75 to 100 percent of the mice that received the drug without the chemical, but none of those who received the combination.
The treatment works like an immunotherapy, uses the immune system to fight the tumor and also trains the body so that it can re-destroy the cancer if it reappears, like a vaccine.
And when the researchers tried to give the cured mice the same cancer again they could not because the jab had immunized them against the tumors.
Additional trials are being planned for exciting therapy that could be a lifeline for the 91,000 Americans and 15,000 Britons diagnosed with melanoma each year.
The scientists injected mice with an immunotherapy drug and a chemical called Diprovocim, which is designed to make the jab work better, and they saw that 100 percent of the mice survived, while between 75 and 100 percent of the mice survived. mice without Diprovocim died
A study by Scripps Research and the University of Texas tested a series of drug combinations in mice with deadly skin cancer.
The researchers used an immunotherapy medication along with several chemicals intended to make it work better.
All the mice were given the anti-PD-L1 drug and in one of three groups the animals were also given a chemical called Diprovocim.
These mice had a survival rate of 100%, while in the other two groups, between 75 and 100% of the animals died.
It is believed that the chemicals used act in the same way in humans.
Researcher Dale Boger said: "This co-therapy produced a complete response, a healing response, in the treatment of melanoma.
"Just as a vaccine can train the body to fight external pathogens, this vaccine enables the immune system to go after the tumor."
When the scientists tried to make the cancer come back, Dr. Boger said: "It would not take. The animal is already vaccinated against that.
The vaccine works by encouraging the body to create white blood cells called leukocytes, which specifically target cancerous tumors.
And it continues to work after the cancer has been destroyed, suggesting that it teaches the body how to fight the disease.
In addition, the drugs were not injected directly into the tumor, but in other parts of the body and were taken to the right place by the immune system.
This suggests that the therapy could even be used to treat tumors that have not been detected by doctors if the body can find them on its own.
The team's findings were published in the journal Proceedings of the National Academy of Sciences.
WHAT IS MELANOMA AND HOW CAN YOU PREVENT IT?
Melanoma is the most dangerous form of skin cancer. It happens after the DNA in the skin cells is damaged (usually due to the harmful UV rays) and then it is not repaired, so it triggers mutations that can form malignant tumors.
The American Cancer Society estimates that more than 91,000 people will be diagnosed with melanoma in the US UU In 2018 and more than 9,000 are expected to die because of it.
- Sun exposure: UV and UVB rays from the sun and tanning beds are harmful to the skin
- Moles: the more moles you have, the greater the risk of having melanoma
- Skin type: fairer skin has an increased risk of melanoma
- Hair color: red heads are at higher risk than others
- Personal history: if you have had melanoma once, you are more likely to have it again
- Family history: if previous relatives have been diagnosed, this increases your risk
This can be done by removing the entire section of the tumor or by the surgeon who removes the skin layer by layer. When a surgeon removes it layer by layer, this helps them discover exactly where the cancer stops so they do not have to remove more skin than necessary.
The patient may decide to use a skin graft if the surgery has left a discoloration or bleeding.
- Immunotherapy, radiotherapy or chemotherapy:
This is necessary if the cancer reaches stage III or IV. That means that the cancer cells have spread to the lymph nodes or other organs of the body.
- Use sunscreen and do not burn
- Avoid tanning outside and on beds
- Apply sunscreen 30 minutes before leaving
- Keep newborns out of the sun
- Examine your skin every month
- Visit your doctor every year for a skin exam
Source: Skin Cancer Foundation and American Cancer Society