Hope for a herpes vaccine after an experiment with an experimental puncture to prevent ulcers and blistering in rodents infected with the virus
- The experimental vaccine prevented animals from developing blisters
- Scientists said the findings & # 39; better than everything & # 39; were they have ever seen
- The researchers hope that it will someday be given to teenagers at school
The hope has been raised from a potential herpes vaccine following the success of an experimental test on animals.
A study showed that the vaccine prevents blistering and ulcers in mice and guinea pigs infected with the HSV-2 strain.
Scientists called the findings & # 39; better than anything & # 39; ever seen, given that efforts to produce a vaccine have failed to date.
An experimental injection developed by American scientists prevented the spread of herpes in an animal study, creating hope that a vaccine would exist in the future
Both types of the herpes strain – HSV-1 and HSV-2 – can cause genital herpes, but is usually caused by HSV-2. It is transmitted through sex.
More often HSV-1 causes ulcers around the mouth and lips and is transmitted by kisses.
Herpes stays in the body for life by lying in sleeping nerves. Every now and then an outbreak is caused when the infection is reactivated.
Blisters that break and become painful are the main symptom of herpes, which can affect the vagina, penis, anus or mouth.
Genital herpes also increases the risk of getting or passing HIV by three to four times, emphasizing the need for a vaccine.
Scientists from the University of Pennsylvania, led by Dr. Harvey Friedman, developed the experimental vaccine for herpes – which is currently incurable.
WHAT ARE HERPED?
Herpes viruses cause cold sores, which usually appear on the lips or genitals.
About seven in ten people in the UK are infected with viruses.
Only about one in three experiences symptoms.
In the US, about half of young adults are infected with the virus that causes cold sores around the mouth.
One in eight has the virus behind genital herpes.
Cold sores on the lips are usually passed on by being kissed by someone with an active cold sore.
They start as a small red spot that blisters before they burst, leaving a rough area that leaves scabs.
Cold sores that appear on the face are usually caused by the herpes simplex type 1 virus.
Type 2 mainly affects the sexual organs.
It is rare for cold sores to spread from the place where they first appeared.
And they are only transmitted through direct skin contact, not by sharing items such as towels or cutlery.
Oral sex is a common way for cold sores to pass from the mouth of one person to the genitals of another or vice versa.
Once infected, patients may initially experience fever and flu-like symptoms.
Cold sores can recur if they are caused by stress, illness, alcohol or too much sunlight.
This is because the virus stays in a nerve node near the spinal cord.
Many feel an itch, tingling or shooting pain before a cold sore reappears.
Antiviral medication can be prescribed if someone often suffers from outbreaks.
By keeping ulcers hydrated, they can stop cracking and become painful.
Source: Herpes Viruses Association
It provided strong protection against & # 39; genital lesions & # 39; in mice and guinea pigs infected with HSV-2 after the vaccine.
The vaccine also prevented low infections – with HSV-2 viruses hiding in nerve cells – in 98 and 80 percent of mice and guinea pigs respectively.
In general, only one out of 64 mice and two out of 10 guinea pigs developed subclinical infections, which may not show symptoms, but when the disease can be transmitted.
This suggests that the risk of transmission is very low, the authors wrote in the journal Science Immunology.
According to New scientist, Dr. Friedman said: & # 39; Our results in mice and guinea pigs & # 39; s are very encouraging – better than anything we've seen in the literature.
& # 39; But we will not know if this vaccine will work until tested in humans. & # 39;
Dr. Friedman and colleagues also want to test whether the vaccine can work against the second type of herpes strain, HSV-1.
If human trials are successful, it is hoped that teenagers will receive the vaccine at school to prevent catching herpes.
Dr. Friedman said no other experimental vaccine has been able to prevent hidden infections in animal experiments – but there are already a few in human trials.
The vaccine consists of messenger RNA molecules, which work differently than conventional vaccines.
RNA vaccines work by introducing an mRNA sequence that contains a code specific to a disease.
The mRNA enters the body cells and tells them how to produce viral proteins, causing an immune response.
The disease is then recognizable by the immune system and prepares it to fight the real infection.
More than one in six people aged 14 to 49 in the US has genital herpes, according to the CDC.
In the UK, seven out of ten people caught one of two species at the age of 25, the state of The Herpes Viruses Association. However, only one in three people has symptoms.
Charity campaign to abolish the stigma surrounding herpes because it is caught by the majority of the population that goes completely unnoticed.
It is caught by having sex with someone when the virus is active on their genitals or by receiving oral sex from someone with cold sores in their faces.
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