That's according to Red legend John Barnes.
Pep Guardiola's team was imperious last year when it became the first club to break the 100-point barrier.
The City are the top favorites to finish at the top this time, but with their rivals strengthening in the transfer window, they face stiff competition.
Liverpool have spent £ 175 million on new faces, while Chelsea and Arsenal could be surprise packages under their respective new managers.
"I think Man City is a favorite once again."
Liverpool legend John Barnes
Tottenham did not sign any signing and Manchester United coach Jose Mourinho has been frustrated by the lack of newcomers and a disappointing preseason campaign.
But despite the concerns of both clubs, Barnes has backed them to maintain their positions in the Champions League.
"Well, I think Man City is a favorite once again, because of the way he played last season," he said. Mirror.
"I do not expect them to get so many points, score so many goals and be so dominant, but I think they will win.
"In fact, I think Liverpool will be the closest, not only because of the harmony they've had since Jurgen Klopp was there, but also because of the signings they've made before.
"They have Naby Keita, Fabinho, Xherdan Shaqiri, they have done their business early, if they had not reached the final of the Champions League last season, I think they could have finished second.
"But with a stronger squad now and the harmony and together they have, added to the quality they already have, I make them second favorites.
"Manchester United, you know that the harmony is not good there, but obviously they have great players, a great manager.
"But harmony is so important and if they get caught too far back they will have trouble catching up.
"Tottenham has not signed anyone, but they will want the players and the team already have to compete for a place in the top four.
"The Arsenal is interesting, because with the arrival of a new manager it will change things … but with most of the same players, that will take time.
"Chelsea with a new manager coming in too, and I think both will be battling for the fourth."
United started the new Premier League campaign last night with a 2-1 victory over Leicester.
The Spurs visit Newcastle today before Chelsea faces Huddersfield.
Liverpool hosts West Ham at Anfield tomorrow before the city's trip to the Emirates to face Arsenal.