A statin dose limits the increased risk of dementia after concussion, the study finds
- Researchers from the University of Toronto studied 30,000 elderly people with concussions
- They found that those who received statins after a blow to the head were 13 percent less likely to develop dementia
Suffering from an old age concussion increases the risk of dementia – but a dose of statins can compensate for this, a new study says.
Researchers from the University of Toronto found that elderly people who received the drug after a blow to the head were 13 percent less likely to get dementia than those who did not.
Rosuvastatin, sold under the Crestor name, was the most effective.
The small but statistically significant gap showed an enormous promise for statins to protect the elderly after a fall
Concussions are usually mild and usually recover.
But, especially with older people, this has been associated with an increased risk of dementia.
Moreover, efforts to develop treatments to compensate for the risk that worked in animal models did not work in humans.
The Toronto team decided to turn to statins, a widely available, inexpensive drug that lowers cholesterol and inflammation – two things that are closely related to dementia.
The observational study looked at 28,815 adults aged 66 and over who were diagnosed with concussions. Most of them (61.3 percent) were women.
A quarter of them got a statin in the 90 days after a concussion, the rest didn't.
The statins include atorvastatin, cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin.
After an average follow-up of four years, one in six or 4,727 patients developed dementia.
Of those using statins, 37 per 1,000 patients developed dementia per year – which is about double the normal rate for this population.
From those who did not Take statins, 43 per 1,000 patients developed dementia – more than double the standard.
The small but statistically significant gap showed an enormous promise for statins to protect the elderly after a fall.
& # 39; Concussion is often popularized as a problem in athletic youth and tends to be under-diagnosed in older people & # 39 ;, said Dr. Donald Redelmeier from the University of Toronto.
& # 39; The results of our study suggest that concussions are a common injury in older adults and indicate that dementia can often be a consequence years later.
Daarom Therefore, more efforts to prevent concussions should be encouraged at all ages.
& # 39; Screening for concussions from the past can also offer new clinical insights for patients with dementia.
& # 39; A possible neuroprotective benefit may also be conducive to improved therapy compliance for patients who have already prescribed a statin.
Bovendien Moreover, concussion should not be interpreted as a reason to stop statins, and a future randomized study is justified.
& # 39; The long-term neurological consequences of concussions are significant and deserve attention. & # 39;
The study was published in JAMA Neurology.
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