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The end of wrinkles can be in sight when scientists at North Caroline State University discover that a new approach was successful in mice. Pictured, their method compared to a check

Botox injections and skin fillers to treat wrinkles are a thing of the past when it is proven that a new natural treatment works.

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Scientists believe that healthy skin cells can one day be stored & # 39; and can be used later in life, when the effects of aging have taken their toll.

Researchers tested the method on mice – brought deep into their skin by air jets, which smooth out their wrinkles within three weeks.

It was also 30 percent more effective than one of the most advanced anti-aging methods that use stem cells, according to the North Caroline State University team.

The developers hope that the technique also works for people and paves the way for a needle-free method to cure wrinkles.

The groundbreaking method works by harvesting skin cells and a molecule that can stimulate collagen production.

The end of wrinkles can be in sight when scientists at North Caroline State University discover that a new approach was successful in mice. Pictured, their method compared to a check

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The end of wrinkles can be in sight when scientists at North Caroline State University discover that a new approach was successful in mice. Pictured, their method compared to a check

Wrinkles are caused by the skin becoming more elastic as you age, because the cells lose their ability to multiply and produce collagen.

Collagen is a protein in the body that forms structures of the skin, hair and nails. It starts to decrease at around the age of 25, accelerated by sun exposure and smoking.

There is no way to stop this, but scientists have tried to find ways to mask the remaining folds – wrinkles.

Researchers focused their attention on exosomes, which are secreted by cells in the body as a way of communicating.

They can transfer information such as DNA, RNA or proteins between cells that can affect the function of the recipient cell.

Professor Ke Cheng and colleagues & # 39; s wanted to see if a dose of human skin cell exosomes could reduce wrinkles in mice.

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Professor Cheng said: & # 39; Consider an exosome as an envelope with instructions in it – like a cell that sends a letter to another cell and tells it what to do.

& # 39; In this case, the envelope contains microRNA, non-coding RNA that instructs the recipient cell to produce more collagen. & # 39;

The researchers exposed mice to ultraviolet B (UVB) light, which accelerates aging and causes wrinkles.

After eight weeks of UVB exposure, the researchers administered human skin cell exosomes to some mice.

To prevent the exosomes from having to be injected with a needle, the team used a device that uses a jet of air to get medicine deep into the skin.

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Three weeks later, the treated mice exhibited considerably thinner wrinkles than the untreated mice due to the boost in collagen.

The skin of the mice treated with exosomes was about 20 percent thicker than that of rodents who received no treatment.

It was also five percent thicker than the mice that received MSC – an anti-wrinkle treatment with bone marrow stem cells.

MSC & # 39; s – mesenchymal stem cells – are a specific type of adult stem cell that is examined as an & # 39; ultimate & # 39; anti-aging treatment.

There was 30 percent more collagen production in skin treated with the exosomes than MSC treated skin.

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The exosomes also worked better than topical retinoic acid, a standard anti-aging cream used on another group of mice.

Professor Cheng said that exosome treatments have two major advantages over conventional treatments.

& # 39; First of all, you can use donor skin cells from everyone to grow and harvest these exosomes – they are not cells, so there is no risk of rejection.

& # 39; And second, treatment can be administered without needles – exosomes are small enough to penetrate the skin through pressure or jet injection methods. & # 39;

Botox temporarily reduces wrinkles by paralyzing facial muscles, creating a & # 39; frozen face & # 39; can cause.

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It also entails risks, just like skin fillers, if it is not done properly.

Professor Chen said: & # 39; Our hope is that people will eventually be able to sample skin samples & # 39; banks & # 39; and to come back to them or to use exotic treatments with donors that they can administer themselves.

& # 39; We believe that this work is an important step toward strengthening future clinical trials in humans to prevent and treat skin aging. & # 39;

The findings were published in the American Chemical Society Nano journal.

WHY DO WE GET WRINKLES?

Wrinkles are folds, folds or ridges in the skin.

They appear normally as people age, but they can also develop after spending a long time in water.

The first wrinkles that appear on a person's face usually occur as a result of facial expressions.

A tendency to smile, frown or blind in a certain way can reinforce folds in certain regions.

Laughing lines and crow's feet tend to be formed by smiles and forehead grooves come from frowns.

Sun damage, smoking, dehydration, some medicines, and environmental and genetic factors also influence when and where people will develop wrinkles.

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Most wrinkles usually appear in the parts of the body that receive the most sun exposure, especially the face and neck, the back of the hands and the arms.

The upper skin layer must be renewed regularly, as it is made from dead cells.

As you get older, it takes longer for your epidermis to renew itself – and it shows more and more signs of your age.

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