Survivors of Seps have a higher mortality risk for years after their fight against life-threatening disease, a study published in JAMA Network Open has revealed

Survivors of Seps have a higher mortality risk for many years after their fight against the life-threatening disease, according to a study.


About one in six patients in England discharged after critical care, admission for sepsis died within a year.

Two in five died within the six-year study period, according to analysis of 100,000 patients.

Elderly people, men and people with complex health were at the greatest risk, because many survivors of sepsis develop complications in the long term.

Worldwide, one third of people who develop sepsis die – at least 46,000 people in the UK and 250,000 people in the US die each year from sepsis.

Survivors of Seps have a higher mortality risk for years after their fight against life-threatening disease, a study published in JAMA Network Open has revealed

Survivors of Seps have a higher mortality risk for years after their fight against life-threatening disease, a study published in JAMA Network Open has revealed


The research led by Dr. Manu Shankar-Hari, from Guy & # 39; s and St. Thomas & # 39; hospital in London, included data from 94,748 patients from 192 intensive care units in England.

All patients survived the hospital discharge after admission of a critical care unit for sepsis between April 2009 and March 2014.

More than two in five (44.1 percent) of those who participated in the study had died at the end of March 2015, according to the study published in the journal JAMA Network Open.

Those who survived the year after their fight were not free of risk, since six to eight percent of the patients who recovered died each year during the next half decade.

Older, male and with multiple health problems appeared to increase the risk of death among survivors of sepsis.

The severity of the condition and the duration of the hospitalization also appeared to be possible risk factors.

Dr. Shankar-Hari, a critical care physician, said: & # 39; This is the first report on the long-term risk of death among sepsis survivors using national data from England.


& # 39; We now know the extent of this long-term risk of death among sepsis survivors.

& # 39; The ability to identify patients with the highest risk is of great importance to us as clinicians, as it helps in planning ongoing care.

& # 39; Given what we now know, we will try to find out what the best interventions are to prevent these deaths, how we can identify those sepsis survivors who are most at risk and more likely to benefit the most from such interventions.

& # 39; More importantly, this new study informs the health policy debate about planning aftercare for survivors of sepsis and survivors of critical illness in general. & # 39;

Sepsis is a serious complication of an infection that occurs when the body's immune system reacts too violently and attacks organs and tissues.


It can lead to multiple organ failure and death if it is not noticed in time.

There are around 250,000 cases of sepsis every year in the UK, according to the UK Sepsis Trust.

Post-sepsis syndrome is a condition that affects up to half of the survivors of sepsis, and it can affect organs such as the lungs, kidneys, and liver, according to Sepsis Alliance.

Psychologically speaking, those who survived sepsis may suffer from insomnia, lively hallucinations and panic attacks, and impaired cognitive function.

Dr. Ron Daniels, the charity's chief executive, said: “It is important that we do not allow these new findings to cause unnecessary alarms for those recovering from sepsis.


& # 39; This study focuses specifically on patients who are admitted to intensive care units, who are already at a higher risk of death or long-term complications after sepsis.

& # 39; While many survivors experience physical, physiological, and emotional after-effects, the majority of people who survive sepsis will fully recover.

& # 39; However, this type of research is important because it underlines the need for better means to inform survivors of the potential risks after sepsis and better follow-up services for those people. & # 39;

Rose Gallagher, of the Royal College of Nursing, said: & Patients who survive sepsis are also left with long-term physical and psychological problems such as post-traumatic stress disorder, chronic pain, fatigue, impaired cognitive function, anxiety, depression and insomnia. & # 39;

Older serious sepsis survivors had a higher risk of cognitive and long-term physical problems than others of their age who were being treated for other diseases, according to a study by the University of Michigan Health System, published in the 2010 medical journal JAMA.


Mr. Gallagher said: & # 39; Life can be a challenge not only for patients but also for their families.

& # 39; The services to support these patients vary from country to country and there is a need for well-funded follow-up services to support their emotional, psychological and physical rehabilitation needs. & # 39;


Sepsis occurs when the body responds to an infection by attacking its own organs and tissues.

About 44,000 people die of sepsis in the UK every year. Someone worldwide dies of the condition every 3.5 seconds.

Sepsis has symptoms similar to flu, gastroenteritis and an infection of the breast.

Among which:

  • Sunclear speech or confusion
  • Extreme shivering or muscle pain
  • Pno urine in a day
  • Salways shortness of breath
  • IIt feels like you're dying
  • Srelated or discolored

Symptoms in children are:

  • Fast breathing
  • Fits or convulsions
  • Spotted, bluish or pale skin
  • Rashes that do not fade when pressed
  • idleness
  • Feeling abnormally cold

Among the five can be repeatedly surrendered, do not feed or do not pee for 12 hours.

Anyone can develop sepsis, but it is most common in people who have recently had surgery, have had a urinary catheter, or have been in hospital for a long time.

Other risk makers are people with a weak immune system, chemotherapy patients, pregnant women, the elderly and very young people.


The treatment varies depending on the site of the infection, but includes antibiotics, IV fluids and oxygen if necessary.

Source: UK Sepsis Trust and NHS Choices

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