British scientists discover & # 39; breakthrough & # 39; compound that can kill superbugs that are resistant to normal medicine and that could one day threaten humanity
- Antibiotic resistance has been described as one of the biggest global threats
- Gram-negative bacteria are listed as urgently needed new treatment
- A compound killed the bacteria, which can cause pneumonia, in laboratory tests
- Scientists said it was almost a decade ago that new drugs were tested
Scientists have discovered a compound that can destroy antibiotic-resistant bacteria and make their work a & # 39; breakthrough & # 39; to mention.
They found a type of chemical called a dinuclear Ru (II) complex that may be able to extensively destroy bacteria for treatment with normal drugs.
Success in laboratory testing has given hope for a new way to tackle superugs, which are becoming more common, more dangerous and harder to stop.
Pneumonia, urinary tract infections and gonorrhea are all caused by the gram-negative type of bacteria used in the tests.
And the estimates estimate that by 2050, 10 million people will die each year as a result of infections that have evolved as untreatable.
Gram-negative bacteria are more difficult to stop taking antibiotics because they have an extra protective membrane on their cell wall and medicines have difficulty getting through the membrane (stock image)
Scientists from the University of Sheffield and Rutherford Appleton Laboratory (RAL) are testing the new compound made from the metal ruthenium.
They called their work a breakthrough after 50 years of developing no new treatments for gram-negative bacterial infections – and since 2010 none have been tested.
Gram-negative bacteria are difficult to destroy because they have an extra protective layer around them, which is difficult for drugs to get through.
But in their research, the scientists discovered that the Ru (II) complex could destroy gram-negative E.coli, which can cause diarrhea and vomiting.
It destroyed the bacteria by damaging the protective membranes around each bacterium, causing them to burst.
"This breakthrough could lead to vital new treatments for life-threatening super bacteria and the growing risk of antimicrobial resistance," said Professor Jim Thomas.
Antimicrobial resistance, also known as antibiotic resistance, is already killing 25,000 people a year in Europe because their infections cannot be stopped.
However, this is expected to increase in the future and the World Health Organization has identified this as one of the greatest dangers to humanity.
Prescribing too much, people who do not use antibiotics and farmers who administer them to animals, would all have contributed to the medicine becoming weaker.
Part of the problem is the ability of the bacteria to evolve when exposed to small amounts of antibiotics and learn how to survive their attacks.
However, this new connection has more than one & # 39; mode & # 39; of activity, the scientists say, meaning that it can be manipulated to target bacteria in different ways.
The research by the Sheffield team was published in the ACS Nano magazine.
They will then test the Ru (II) complex against various types of antibiotic-resistant bacteria before testing their effects on mammals.
HOW MEAT BERRIES COULD HELP TO TAKE ANTIBIOTIC RESISTANCE
Cranberries can make antibiotics more effective and prevent bacteria from becoming resistant, research has shown.
Scientists from McGill University in Montreal, Canada, found cranberry extract, which made it easier for drugs to penetrate the wall of a bacterial cell and prevent the bacterium from pumping out the attacking drug.
& # 39; Normally if bacteria are treated with an antibiotic in the lab, eventually the bacteria get resistance & # 39 ;, said Professor Nathalie Tufenkji, lead author of the study.
& # 39; But when we simultaneously treated the bacteria with an antibiotic and the cranberry extract, no resistance developed.
& # 39; We were very surprised by this and we see it as an important opportunity. & # 39;
The researchers said that molecules called proanthocyanidins were the cause of this effect, and there are several types that can work together.
They said the results, published in the Advanced Science journal, & # 39; exciting & # 39; justify more research in the fight against antibiotic resistance.
If the technique works, it may mean that people can take lower doses, thus extending the life of existing medicines.
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