Schizophrenia can someday be discovered by testing human HAIR, scientists claim
- Tests show that patients with mental disorder have higher levels of MPST
- Japanese researchers looked at mice, post-mortem monsters and living people
- Approximately one in 100 people in the UK and the US will undergo a schizophrenic episode
Schizophrenia can someday be discovered by testing human hair for levels of a particular enzyme, scientists have claimed.
Tests show that patients with severe mental disorder have much higher levels of MPST than those without.
The Japanese team now says that looking for levels of the enzyme in the hair can help recognize the condition before patients get hallucinations.
And they say they are now testing whether drugs designed to tackle enzyme production can relieve the symptoms in mice.
Tests show that patients with severe mental disorder have much higher levels of MPST than those without
About one in 100 people in the UK and the US will experience a schizophrenic episode at some point in their lives, statistics show.
There is no test for the condition. Most patients are diagnosed by mental health specialists after experiencing one or more symptoms during a month.
WHAT IS SCHIZOPHRENIA?
Schizophrenia is a chronic and serious mental disorder that affects how a person thinks, feels and behaves.
People with schizophrenia may seem to have lost touch with reality.
The cause of schizophrenia is not understood and it is believed to be a mix of genetics (hereditary), abnormalities in brain chemistry and / or possible viral infections and immune diseases.
Symptoms of schizophrenia usually begin between the ages of 16 and 30. In rare cases, children also have schizophrenia.
The symptoms of schizophrenia fall into three categories: positive, negative and cognitive.
Positive symptoms are disorders that are added & # 39; to the personality of the person and include:
- Thought disorders (unusual or dysfunctional ways of thinking)
Negative symptoms are possibilities that & # 39; lost & # 39; are of the personality of the person and include:
- & # 39; Flat affect & # 39; (reduced expression of emotions through facial expression or voice)
- Decreased feelings of pleasure in daily life
- Difficult to start and support activities
Cognitive symptoms are changes in their memory or other thinking aspects and include:
- Problems with focusing or paying attention
- Problems with & # 39; RAM & # 39;
- Poor ability to understand information and use it to make decisions
Figures suggest that about one percent of the world's population suffers from schizophrenia, with about two million in the US.
Source: National Institute of Mental Health
Symptoms include hallucinations, decreased sense of pleasure and difficulty focusing or paying attention.
Researchers at the RIKEN Center for Brain Science, on the outskirts of Tokyo, started studying two groups of mice.
One of them had low pre-pulse inhibition (PPI), a sign of schizophrenia. The other rodents had a higher PPI – which means that bursts of noise scare them more.
The results showed mice with the significant sign of mental health status that expressed much more MPST, which produces hydrogen sulfide, in their brains.
Further results – published in EMBO Molecular Medicine – showed that they also had much higher hydrogen sulfide levels.
Before he looked at people, Dr. proved Takeo Yoshikawa and colleagues & # 39; s that MPST was to blame for analyzing genetically modified mice.
They then looked at MPST levels in post-mortem brain samples from patients with schizophrenia and compared them with non-affected people.
Levels appeared to correlate with the severity of the symptoms, suggesting that larger amounts could cause patients to get more hallucinations.
Dr. Yoshikawa and colleagues then analyzed hair follicles from 300 people, about half of whom were familiar with schizophrenia.
As with mice, the expression of MPST was much higher in patients with mental disorder compared to patients without.
Further results then showed that hydrogen sulfide can cause permanent DNA and lead to & # 39; sulfide stress & # 39; induced schizophrenia.
Dr. However, Yoshikawa and colleagues & # 39; s would like to point out that this does not cause every case of mental health.
& # 39; A new paradigm is needed for the development of new drugs, & # 39; he said, adding that our medicines can offer that opportunity.
& # 39; Currently, about 30 percent of patients with schizophrenia are resistant to dopamine D2 receptor antagonists.
& # 39; We are currently testing whether inhibiting hydrogen sulfide synthesis can relieve symptoms in mouse models of schizophrenia. & # 39;
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