Scientists discover that physical activity reduces the risk of heart disease by causing unhealthy white blood cells that cause inflammation and clogging blood vessels – and say this can lead to treatment with & # 39; holy grail & # 39;
- Researchers split mice into two groups, one that did not have treadmills in cages and one that did have treadmills
- The mice that trained regularly had lower cells that could turn into white blood cells, which increases inflammation
- Chronic inflammation leads to the formation of plaques that block the arteries and can cause cardiovascular disease
- Mice that exercise also produced less leptin, which is a hormone that is responsible for controlling appetite and can cause inflammation if the levels are too high
Regular exercise can reduce inflammation and help protect against heart disease, a new study suggests.
In research on mice, scientists from the Massachusetts General Hospital looked at one group of rodents who walked on treadmills daily and one group that did not.
The mice that were trained every night had lower levels of a type of immune system cell that can turn into white blood cells.
This reduced their risk of chronic inflammation, which contributes to the formation of plaques that block the arteries and can cause cardiovascular disease.
A new study by the Massachusetts General Hospital in mice has shown that exercise lowers the overproduction of white blood cells, which reduces inflammation and the risk of heart disease (file image)
Heart disease is currently the largest killer in every country, including the US.
According to the National Institutes of Health, the risk of coronary heart disease starts to rise for men at the age of 45 and for women at the age of 55.
To improve overall heart health, the American Heart Association recommends training at least 150 minutes a week with a moderate intensity or at least 75 minutes a week with a high intensity.
For the study, published in the journal Nature Medicine, the team studied mice that were divided into two groups.
One group was placed in cages with treadmills, where some rodents ran six miles a night.
The second group was placed in cages without treadmills. The two groups were compared after six weeks.
Researchers discovered that the mice running on treadmills had found reduced levels of cells in the bone marrow known as hematopoietic stem and progenitor cells (HSPC & # 39; s).
HSPCs can change into any type of blood cell, including white blood cells called leukocytes, which increase inflammation.
Inflammation helps plaques grow, which can clog arteries and cause blood clots and can lead to heart disease, heart attacks and strokes.
& # 39; We were surprised by how many mice enjoyed running & # 39 ;, lead author Dr.. Matthias Nahrendorf from the Center for Systems Biology at the Massachusetts General Hospital at DailyMail.com.
& # 39; But we were also surprised that the effects of running remained with the mice for a while, until two to three weeks thereafter (the end of the study period). & # 39;
In addition, researchers discovered that the mice that trained produced less leptin, which is a hormone that is responsible for controlling appetite.
Previous studies conducted by the team showed high levels of leptin and leukocytes in people with cardiovascular disease-related infections.
Dr. Nahrendorf said the results demonstrate the importance of exercise, but also how this can lead to new therapies for preventing heart attacks and strokes
& # 39; In the future, we want to look for ways that, such as exercise, reduce the overproduction of white blood cells because that reduces inflammation, & # 39; he said.
& # 39; I am not saying we would have a pill, but if we could find a way to reduce inflammation – hitting the pathways with medication – that would be the holy grail in anti-inflammatory therapy. & # 39;
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