Recommended Dosage Norms for The Usage of Fenbendazole

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The daily dosage for fenbendazole may vary, with respect to the health condition of the patient as well as chemotherapy and suggested medications.

Dosage guideline

Please note: It is important to first reach out to a certified, professional medical consultant who has adequate experience and attitude in fields relating to combinatorial cancer treatment and traditional chemotherapy before combining fenbendazole with extra supplements, nutraceuticals, natural products, pharmaceuticals, or chemotherapy to avoid possible adverse effects of combining chemicals or medications.

Fenbendazole comes in either capsule, tablet, or powder form and should be stored below 25 C without sun exposure.

Side effects, metabolism, and toxicity of fenbendazole

Determining the specific side effects and health outcomes of normal or high doses of fenbendazole in humans is usually very difficult since it is primarily not a human medication and has no previous documentation on human usage. Predicting the side effects or combining fenbendazole with other medications is even more difficult.

Consuming fenbendazole tablets orally alone has highly reduced acute toxicity (according to measurements taken from mice). There is zero acute oral exposure limit (in a situation where the threshold for acute toxicity is more than 5000mg for every kg of body weight).

From studies carried out on humans, it is discovered that there were no adverse effects for doses of about 500mg per individual. Also, there are no adverse effects from using doses of about 2000mg per individual.

According to different laboratory and human trials on genotoxicity tests carried out by the European Medicines Agency, which is Europe’s drug regulator, has announced that the fenbendazole drug does not cause mutations in DNA. European regulators have been evaluating the safety of fenbendazole and have not found any risks. A two-year research in rodents revealed an evidence for carcinogenicity. Research on carcinogenicity, genotoxicity, and toxicity can be retrieved fromUS National Library of Medicine.

Side effects

Some of the side effects are:
Liver injury – extremely rare
Skin itching – very rare
Jaundice – very rare
Vomiting – rare
Diarrhea – rare

Metabolism

The two-body transformation that occurs after fenbendazole is absorbed in the body is oxidation and hydroxylation.

The initial process occurs through two liver enzymes – CYP212 and CYP2C19. The hydroxylation of fenbendazole creates a new metabolite known as hydroxy fenbendazole.

The second procedure involves the oxidation of the sulfide group. The flavin-content monooxygenase and enzymes CYP3A catalyze it in the liver. This results in the formation of a new compound known as oxfendazole (that comes with anthelmintic and anti-cancer properties).

The fascinating part is that these discoveries reveal that it can both act as medication and prodrug that can be used to reproduce another active medication.

Fenbendazole, in particular, is not entirely converted into its metabolites as a result of its low bioavailability. Our gastrointestinal tract only absorbs a small fraction of the fenbendazole. In the end, hydroxy fenbendazole, ox fenbendazole, and fenbendazole are released with our feces.

Remember that CYP2C19, an enzyme responsible for the metabolization of fenbendazole also metabolizes medications such as apixaban, astemizole, ebastine, thioridazine, amiodarone, cyclosporine, and tamoxifen.

It is very important to first consult a medical consultant for possible interactions whenever an individual decides to combine fenbendazole with any of these drugs and obtain more information on potential side effects and enhanced toxicity.

To find out more visit our website: https://www.fenbenlab.com/