The installation of Joe Gomez with Virgil van Dijk on the center side, coupled with the continuous improvement of the youths Andrew Robertson and Trent Alexander-Arnold and the addition of Alisson, makes the current Liverpool defense much more difficult to break than in their last meeting. visit to Wembley.
Harry Kane ran riot in October of last year, scoring twice and forcing Klopp to replace Dejan Lovren after only 30 minutes, while the Spurs won a 4-1 victory.
Kane will be eager to return to the goals with persistent questions about his fitness and fitness in a hangover from the 2018 FIFA World Cup since he picked up the Golden Boot in Russia.
And there will be even more responsibility on Kane's shoulders with captain Hugo Lloris and Dele Alli ruled out by injury.
The defeat at Watford just before the international break punctured the Spurs' own drive to be considered contenders for the title.
But the Spurs' victory will take them to the level of Liverpool at the top of the table at least a few hours before other forwards, Chelsea, Watford and Manchester City, enter action later on Saturday.
More grief from the United Kingdom in Watford?
Watford is the first surprise package of the season thanks to four consecutive victories to be with the pacemakers Liverpool and Chelsea.
The head of the Hornets, Javi Gracia, has earned a reputation for the scalp, beating Barcelona and Real Madrid during his time in Spain with Málaga, and defeating Chelsea 4-1 in their first match in charge on Vicarage Road to beat the Spurs two weeks ago.
United returned to the track with a comfortable win at Burnley before the international break to calm the storm surrounding the future of José Mourinho.
But if Mourinho's men suffered a third loss in five league games, the chances of catching players like Liverpool and City would already be sad.
Pellegrini needs points
At the other end of the table, West Ham remains the only team without a point after four games, despite a large transfer fee of almost 100 million during the summer.
Former Man City manager Manuel Pellegrini has not only been supported in the transfer market, but also with the patience of the Hammers hierarchy.
However, the Chilean is now the favorite to be the first manager of the Premier League of the season to be fired and his chances will only be shortened if he fails to inspire a response to Everton on Sunday.
Fixtures (all GMT hours):
Tottenham v Liverpool (1130), Bournemouth v Leicester, Chelsea v Cardiff, Huddersfield v Crystal Palace, Manchester City v Fulham, Newcastle v Arsenal (all 1400), Watford v Manchester United (1630)
Wolves v Burnley (1230), Everton v West Ham (1500)
Southampton v Brighton (1900)