Fabian Delph, who had won seven caps of England since his last appearance in the first team for City in May, was also given a place in Guardiola's starting eleven, just three days after national team manager Gareth Southgate said His concern that some of his players suffer from a lack of regular competitive football.
And although Guardiola will have little interest in Southgate's problems, his ability to rotate his team with such high quality replacements is a good omen, as the City will embark on Champions League and League Cup campaigns as well. of their league commitments.
For City's chances of adding to the two trophies, which they won last season, a return to form by Sane, which Guardiola had left on the bench during the first month of the campaign, could be very significant. The PFA Youth Player of the Year from last season had endured a four-month attempt in which he was also omitted from the German World Cup team.
Liverpool's impressive midday victory at Tottenham had exerted an additional element of pressure on the defending champions, but City took less than 100 seconds to take the lead.
However, Fulham was the architect of his own fall, as Marcus Bettinelli's authorization for Jean Michael Seri resulted in a low impact pass that Fernandinho stole from receiver Denis Odoi.
The Brazilian went ahead in the Fulham area and clocked his cross to perfection, beating Bettinelli's dunk and playing in Sane who hit the ball from six yards.
It was the start of a dominant afternoon for the City and a test for a Fulham defense without a clean sheet and with nine goals conceded in the first four games of the league.
Bernaldo Silva played with excellent skill in the midfield and played clean for England's goal, but the English international hit the crossbar.
But Fulham bowed to the inevitable in the 21st minute after a more outstanding move from Bernardo, who avoided the great challenge of Stefan Johansen and returned the ball to Sergio Agüero, whose effort was blocked by Odoi.
The ball fell kindly to David Silva, who controlled him high on his chest, which caused Fulham to claim handball, before burying him on the roof of the net from close range.
Fulham, whose offensive play showed promising moments, finally forced Ederson to a pair of saves from Andre Schurrle's shots.
There was still time for Sane to put the ball into the net, only for the "goal" to be discarded for offside, but City needed only 97 seconds of the second half to score again.
Sterling broke from the depths of his own half with a strong and skillful maneuver before David Silva's magnificent cross-field ball found Aguero on the right.
The Argentine selflessly drove in the area before drilling the ball through an open goal line where Sterling converted.
Bernardo Silva had a deflected goal shot shortly after, while substitute Gabriel Jesus saw an effort close to the post saved by Bettinelli when City threatened a defeat.
Fernandinho and Sterling were also close to long range shots while the entire second half went by without Ederson having problems in the home court until the injury time when he threw himself to deny the chance of Aleksandar Mitrovic.