Officials remind MORE batches of two drugs for Parkinson's & epilepsy

Officials remind MORE batches of two Parkinson's and epilepsy medications amid fears that they have been stored incorrectly and may be ineffective

  • Neupro and Vimpat are recalled by the British drug regulator
  • There are concerns that they have been stored incorrectly and may not work properly
  • There was a recall of the same medication from another company last month
  • Patients are advised to contact their pharmacist if they are affected
  • People should not stop taking medication without the permission of their doctor
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More batches of two types of Parkinson's and epilepsy medicines have been recalled by the UK drug regulator.

Patients taking certain types of Neupro and Vimpat medicines are encouraged to check whether theirs are affected by the recall.

Those affected by the Kosei Pharma, MPT Pharma, Drugsrus, P.I.E Pharma or Doncaster Pharmaceuticals labels are among those affected.

The announcement comes after three other batches of the same medication were recalled last month.

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The medicines may have been stored at the wrong temperature, which may mean that they are less effective than they should have, the Medicines and Healthcare Products Regulatory Agency (MHRA) have warned.

The British medicines and medicines regulatory authority has recalled more batches of Vimpat and Neupro medicines after concerns about this were first raised last month (stock image)

The British medicines and medicines regulatory authority has recalled more batches of Vimpat and Neupro medicines after concerns about this were first raised last month (stock image)

Parties involved are all in Italian packaging with a label of one of the above-mentioned British medicines.

The MHRA said it didn't worry that the drugs were fake or illegal, but it couldn't be certain that they were safely stored or transported.

If medicines get too hot or too cold – these are stored in Italy – the chemicals in them can physically change, which may make them less effective.

Other drugs were affected by the supply chain disruption, but only Neupro and Vimpat are recalled from patients.

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Neupro patches stick to the skin and release a drug called rotigotine to treat the symptoms of Parkinson's disease.

And Vimpat, which is supplied in tablets, is an anti-epileptic medicine that is given to patients over the age of four who have epilepsy.

Earlier versions of the same drugs that were recalled had labels from a company called B&S Healthcare.

Dr. Andrew Gray from the MHRA said: “Ensuring that the drugs that people and their families use is acceptable safe and effective is the primary role of the MHRA and is our top priority.

& # 39; When we are made aware of potential risks to the security of the supply chain, the MHRA takes action to protect the public.

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& # 39; Following new information, we issued this further warning to ensure that pharmacies have the information they need and to protect public health.

"We are constantly striving to ensure that the UK regulated supply chain remains one of the safest in the world."

Patients are warned to ask their doctor or pharmacist if they think their medication is in one of the affected parties, but not to stop on their own initiative.

All involved have an expiration date between July 2019 and April 2023.

HOW CAN HIGH OR LOW TEMPERATURES WORK WITH DRUGS STOP?

Medicines are usually supplied with storage instructions that determine whether they should, for example, be stored in the refrigerator or at room temperature.

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How medicines are stored is crucial to ensure that they remain effective in the period before a patient has to take them.

Many medications must be stored between 2 ° C and 8 ° C – refrigerator temperature, while some must be lower than 15 ° C or lower than 25 ° C – room temperature.

If medicines are not stored within the safe storage limits, the chemicals in them can be damaged.

Extreme temperatures or cold can irreversibly damage the form of proteins needed to make the medication work. For antibiotics, for example, if the chemical structure of a drug changes, it may lose its ability to attach to the bacteria or viruses it is designed to fight.

Temperatures can also cause physical changes in drugs that are not completely solid.

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Mixed emulsions, suspensions or suppositories can separate or settle at certain temperatures, while components in liquid drugs can crystallize if they become too cold.

And some drugs contain chemicals that only dissolve in liquid at certain temperatures, so if they get too hot or cold, they can become unstable.

Source: Medicines Control Agency

WHICH PARTIES ARE AFFECTED? (Source: MHRA)
Product Name Italian batch number Batch number of brand Expiration date release date
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56659401 56659401/7 Oct-19 28/02/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56659403 56659403/5 Oct-19 23/05/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56666402 56666402/9 Nov-19 2018/09/03
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56666402 56666402/12 Nov-19 23/05/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56666403 56666403/1 Nov-19 2018/09/03
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56670401 56670401/2 Dec-19 2018/01/03
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56670401 56670401/8 Dec-19 23/05/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56670401 56670401/9 Dec-19 14/06/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56670401 56670401/11 Dec-19 26/09/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56679402 56679402/1 Jan-20 14/03/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56679402 56679402/9 Jan-20 13/07/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56679402 56679402/11 Jan-20 22/01/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56688403 56688403/4 Feb-20 23/05/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56688403 56688403/7 Feb-20 28/08/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56688403 56688403/11 Feb-20 10/22/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56688403 56688403/15 Feb-20 10/22/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56695404 56695404/1 Mar-20 24/05/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56695404 56695404/3 Mar-20 2018/11/06
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56695404 56695404/5 Mar-20 2018/12/06
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56695404 56695404/8 Mar-20 10/22/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56695404 56695404/13 Mar-20 10/22/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56699404 56699404/1 April-20 14/06/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56699404 56699404/2 April-20 10/22/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56699404 56699404/5 April-20 11/21/2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56699404 56699404/8 April-20 31.12.2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56699404 56699404/15 April-20 31.12.2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56699404 56699404/16 April-20 31.12.2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56712403 56712403/1 Jun-20 31.12.2018
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56712403 56712403/2 Jun-20 21/01/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56712403 56712403/4 Jun-20 18/02/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56712404 56712404/1 Jun-20 2019/10/01
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56712404 56712404/2 Jun-20 24/01/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56712404 56712404/4 Jun-20 18/02/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56722401 56722401/1 July-20 18/02/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56728403 56728403/1 August 20 18/02/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56728403 56728403/4 August 20 18/02/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56737110 56737110/1 Sep-20 25/02/2019
KOSEI NEUPRO 4MG / 24HR TRANDERMAL PATCHES 1 X 28 56742401 56742401/2 Nov-20 28/02/2019
KOSEI VIMPAT 100 MG TABLETS 1 X 56 248884 248884/11 Dec-22 2019/05/02
KOSEI VIMPAT 100 MG TABLETS 1 X 56 252026 252026/5 Jan-23 2019/05/02
KOSEI VIMPAT 100 MG TABLETS 1 X 56 254,265 254265/4 April-23 20/02/2019
KOSEI VIMPAT 100 MG TABLETS 1 X 56 255,279 255279/1 April-23 20/02/2019
MPT PHARMA NEUPRO 4MG / 24H TRANSDERMAL PATCH 1 x 28 56666402 136,496 2019/01/11 2018/12/04
MPT PHARMA NEUPRO 4MG / 24H TRANSDERMAL PATCH 1 x 28 56666403 134,565 2019/01/11 2018/12/04
MPT PHARMA NEUPRO 4MG / 24H TRANSDERMAL PATCH 1 x 28 56670401 134,568 2019/01/12 13/04/2018
MPT PHARMA NEUPRO 4MG / 24H TRANSDERMAL PATCH 1 x 28 56679402 134567 2020/01/01 19/03/2018
Doncaster Pharmaceuticals Neupro 4 mg / 24 hour transdermal patch 1 x 28 56688403 56688403/0079 Feb-20 2018/06/08
Doncaster Pharmaceuticals Neupro 4 mg / 24 hour transdermal patch 1 x 28 56679402 56679402/0079 Jan-20 17/08/2018
Doncaster Pharmaceuticals Neupro 4 mg / 24 hour transdermal patch 1 x 28 56649401 56649401/0079 August 19 22/08/2018
Doncaster Pharmaceuticals Neupro 4 mg / 24 hour transdermal patch 1 x 28 56695404 56695404/0079 Mar-20 2018/10/09
Drugsrus / P.I.E Pharma Neupro 4 mg / 24 hour transdermal patch 1 x 28 EU / 1/05/331/005 56695404 C23275 Mar-20 2019/08/04

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