It happened shortly before 3 am at the junction with Waterworks Road Roundabout in Walthamstow, northeast of London.
The driver of the car that hit the truck, which is believed to be about 30 years old, was pronounced dead at the scene.
The man had not stopped before the police before the accident.
But so far the police have not said if they were chasing the car at the time of the collision.
The case has been referred to the Met's Office of Professional Standards and is being investigated by the Independent Office of Police Conduct.
The Metropolitan Police said: "Around 02:54 on Sunday, October 21, a car was involved in a truck crash on the A406 North Circular Road at the junction with the Waterworks roundabout, E17.
"Emergency services attended and the car driver, who is believed to be over 30 years old, was pronounced dead at the scene.
"We are not aware of any other injury, nor do we believe that there is another person in the car.
"Before the collision, the car had not been stopped by the police.
"The Met's Office of Professional Standards has been informed and the Independent Office of Police Conduct has initiated an independent investigation."
At 3.17pm, @TfLTrafficNews said that the road where the accident occurred has now reopened in both directions.
He tweeted: "Update on the A406 incident: the eastbound road now has also reopened after the collision during the night.
"Residual Restrictions of the Angel Road Overpass Westbound traffic flows well."