Men’s brains have similar genes and proteins commonly found in testicle finds

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Intelligence has previously been linked to sperm quality, an idea that may now be confirmed as scientists have discovered that the male brain and testicles share a number of similarities.

A team of scientists led by the University of Aveiro in Portugal compared proteins from 33 tissue types and found that testicles and brain share more than 13,000 proteins, many of which are involved in tissue development and cell communication.

The study also found similarities in human neurons and sperm, as they both undergo exocytosis: neurons use this process to pass neurotransmitters on to each other, and sperm use it when fusing with an egg.

Exocytosis is the process of moving material inside a cell to an outside environment.

“This is an underexposed topic and the relationship between these tissues needs to be elucidated, which could help to understand the dysfunctions that affect the brain and testis. [singular]and to develop improved therapeutic strategies,” researchers shared in the study, published in the journal Royal Society.

The human brain is the most complex and unique organ in the body, but a new study has identified another with similar properties: the male testicle.  A team of scientists discovered that the brains and testicles of men have a number of cellular and molecular similarities

The human brain is the most complex and unique organ in the body, but a new study has identified another with similar properties: the male testicle. A team of scientists discovered that the brains and testicles of men have a number of cellular and molecular similarities

The research was conducted by scientists from Portugal and the UK, who began their work by comparing different tissues, including the brain, testis, heart, cervix and placenta.

“Of the total of 14,315 and 15,687 proteins that make up the human brain and testicular proteome, respectively, 13,442 are common to both tissues,” the team wrote in the study.

A majority of the proteins are involved in exocytosis, tissue development and cell communication, which the team was not surprised to learn given the similar functions of the two tissues.

The brain and testis require large amounts of energy for primary tasks – thinking and producing several million sperm per day, Science Alert reports.

The study also found similarities in human neurons and sperm, as they both undergo exocytosis: neurons use this process to pass neurotransmitters on to each other, and sperm use it when fusing with an egg.

The study also found similarities in human neurons and sperm, as they both undergo exocytosis: neurons use this process to pass neurotransmitters on to each other, and sperm use it when fusing with an egg.

“Of the total of 14,315 and 15,687 proteins that make up the human brain and testicular proteome, respectively, 13,442 are common to both tissues,” the team wrote in the study.

This makes both tissues susceptible to oxidative stress that can lead to cell and tissue damage.

To counteract this problem, the two have their own protective barrier: a blood-brain barrier and a blood-testicular barrier.

One of the findings was that some of the common proteins undergo exocytosis in the brain.

When exocytosis occurs in the brain, cells pass on neurotransmitters to each other and this is an important process during fertilization.

Exocytosis stimulates the growth of neurons, allowing them to grow branching arms, and for sperm, the process aids in fusing with an egg.

By looking more deeply at the two tissues, the team concluded that the neurons of the brain and the sperm of the testis have similar characteristics.

The team eventually identified 5,048 common proteins in human neurons and sperm

The team eventually identified 5,048 common proteins in human neurons and sperm

“Different types of ‘neuronal’ receptors, such as glutamate and gamma-aminobutyric acid (GABAA), glycine and nicotinic acetylcholine receptors, have been found in semen,” the study said.

‘In sperm, too, the ‘neuronal’ receptors play a vital role for normal function, including in the acrosomal response, capacitation and motility of sperm.’

The team eventually identified 5,048 common proteins in human neurons and sperm.

‘The human neuron and sperm are very different cells; however, they share different molecular features, and a large number of proteins are common to both cells, primarily those involved in exocytotic and cell signaling processes, tissue development and brain/neuron-associated processes,” the study added.

Understanding these similarities and their implications has become a topic of interest among the scientific community. Indeed, a relationship between intelligence and some sperm quality parameters has been reported and a link has also been shown between dysfunctions of the human brain and testis.”

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