Unai Emery makes two changes from his win against Arsenal, as Matty Cash and Douglas Luiz replace Diego Carlos and Morgan Rogers.
That will see Ezri Konsa return to his natural central position, as opposed to the full-back role he played at the Emirates.
Meanwhile, the locals add Yusuf Yazici to the attack, in the only change after the defeat in the first leg.
Lille XI: Chevalier, Tiago Santos, Diakite, Yoro, Ismaily, Andre, Bentaleb, Yazici, Haraldsson, Gudmundsson, David.
Substitutes: Mannone, Ngrel, Alexsandro, Gomes, Cabella, Ounas, Cavaleiro, Morais, Bouaddi, Touré, Ferrah.
Villa XI: Martínez, Cash, Konsa, Pau, Digne, Luiz, Tielemans, Diaby, Zaniolo, McGinn, Watkins.
Substitutes: Olsen, Gauci, Carlos, Lenglet, Durán, Rogers, Kelser-Hayden, Bailey, Iroegbunam, Munroe, Kellyman.
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