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HomeHealthIntimate way to take drugs that cuts side-effects for women

Intimate way to take drugs that cuts side-effects for women

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Every day in the UK we swallow tens of millions of tablets for everything from pain to high blood pressure.

While a handful of conventional medications are available in the form of creams, gels, and patches, an estimated 85 percent of our medication intake is taken orally.

And now scientists are investigating (for about half the population, at least) a slightly less obvious approach. Because there can be drawbacks when taking medications by mouth. The drugs travel to the stomach, where they are absorbed through its lining and into the bloodstream before being transported to where they need to work.

However, this means that the drugs can cause side effects in other parts of the body. And common treatments, like some antibiotics, can irritate the gut; pain relievers such as aspirin can cause stomach bleeding.

Also, because stomach acid destroys some of the drug, many pills have to come in higher doses than necessary to make up for the loss. Therefore, there is scope for alternatives, delivering the drug directly to where it is needed, and a vaginal route may be a solution.

While a handful of conventional medications are available in the form of creams, gels and patches, an estimated 85 percent of our medication intake is by mouth (File Image)

It is not a new idea. In Ancient Egypt, vaginally administered remedies included a contraceptive made from crocodile dung, honey, and baking soda.

Modern medicine already deploys the vaginal route, mainly for local symptoms. Low doses of estrogen for menopause can be given as a cream, gel, or tablet into the vagina.

The NHS website states that vaginal estrogen does not carry the usual risks of HRT. This is because TRH taken by mouth is carried throughout the body in the blood.

Vaginal HRT also gets the drug where it’s needed, to combat the dryness and burning sensation or pain some menopausal women experience during sexual intercourse.

Giving powerful drugs this way can also make the drugs work much faster.

The walls of the vagina offer a large area teeming with hundreds of tiny blood vessels near the surface, through which drugs can be rapidly absorbed. Lower doses can also be used, as none is ‘lost’ on the long journey around the body.

Until now, there has been little work on this means of drug delivery.

“It’s fair to say it’s been underexploited,” says Karl Malcolm, a professor of pharmacy and an expert in drug delivery at Queen’s University Belfast, adding that “one of the main reasons for this is cultural barriers.”

Most women with endometriosis are given hormonal drugs or birth control to control inflammation, or have surgery to remove endometriosis tissue (File Image)

Most women with endometriosis are given hormonal drugs or birth control to control inflammation, or have surgery to remove endometriosis tissue (File Image)

However, things are changing. One area attracting considerable research interest is the treatment of cervical cancer. While current treatments—radiation therapy, surgery, chemotherapy, or a drug called bevacizumab (Avastin)—are often successful, there are potential side effects: Avastin, for example, given as an infusion into the arm, can cause deep vein thrombosis. a dangerous blood clot, in about one in 100 patients.

Now, scientists from the University of Mississippi in the US report that they have developed a vaginal film, which adheres to the inner wall, using 3D printing technology. The film contains disulfiram, an oral medication used to treat alcoholism but has also been found to kill cancer cells in the cervix.

Tests on sheep showed that the film consistently released the cancer drug over a 24-hour period, raising hopes that it could be developed as a once-daily treatment for women with the disease, according to results published in the journal International Journal of Pharmacy.

A similar breakthrough was recently made at the University of Bern in Switzerland, where scientists also used 3D printing technology to create egg-shaped vaginal implants to treat endometriosis.

The condition causes heavy, distressing periods when the tissue that normally forms the lining of the uterus begins to grow in other places, such as the ovaries and bladder, and even, though rarely, the brain. This tissue behaves like the tissue of the uterus, swollen and bleeding with menstruation, causing inflammation, pain and scarring.

The tiny ‘eggs’, no larger than a paracetamol tablet and coated with an adhesive to adhere to the vaginal wall, gradually release a drug called pirfenidone, which has been shown to reduce scarring and tissue growth caused by endometriosis. reported the European Journal. of Pharmaceutical Sciences in June.

Currently, most women with endometriosis are given hormonal medications or birth control to control inflammation, or have surgery to remove the endometriosis tissue.

“From an anatomical perspective, the vagina is obviously close to the uterus, so there’s a big push right now to find ways to use it for the treatment of endometriosis,” says Professor Malcolm.

This approach can also help combat loss of libido.

Research published in Obstetrics and Gynecology Science in May showed that postmenopausal women who received a vitamin D-loaded vaginal suppository, which remained in situ for eight weeks, had significantly better appetite and sexual function than women who received a vaginal suppository. placebo. The vitamin is believed to increase blood flow to the genitals.

Laura Wilson, Scotland director of the Royal Pharmaceutical Society, says there is considerable potential in the UK for wider use of vaginally administered medicines.

She adds: ‘In France and other EU countries, rectal suppositories are the preferred route of drug administration in children, which means you can use a lower dose and with fewer side effects.

“But we are more secretive in the UK and neither this type of drug administration nor vaginal delivery is widely discussed.

“There is potential for broader use of both, but we need to educate patients about the benefits.”

Merryhttps://whatsnew2day.com/
Merry C. Vega is a highly respected and accomplished news author. She began her career as a journalist, covering local news for a small-town newspaper. She quickly gained a reputation for her thorough reporting and ability to uncover the truth.

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