A girl with eczema that was so severe that it had kept her awake all night has seen a dramatic recovery after taking a chemotherapy drug.
Rev. Stanmore was so exhausted that she could not go to school and had to give up dancing and swimming lessons because of her chronic skin condition.
The dry, raw skin of the nine-year-old made her have stained sheets and she even had so much trouble eating.
But Hope's skin has been cleared after participating in an NHS research trial at Churchill Hospital in Oxford.
She was given methotrexate, a drug that is commonly used to treat patients who have neck, lung, and breast cancers.
The eczema of honor Stanmore was so violent that it kept her awake and scratched all night and was unable to eat food
The girl was so exhausted that she stopped going to school and her dry, raw skin left her with bloodstains
Her mother Laura Klee (36) said: “She was so bad she couldn't eat because she had eczema all around her mouth, so it was very painful to open her mouth and prick food like tomatoes.
& # 39; That's when I thought, "Good, this isn't good." It was not only hobbies and education that was affected, it was her basic life levels that she could not use without discomfort.
& # 39; She itchy from the moment she woke up to the moment she went to sleep and became depressed. & # 39;
Honor, from Witney, Oxfordshire, was diagnosed with just four weeks old eczema.
It was treated with steroid creams until 2016, when her eczema became more severe and began to affect her daily life.
Eczema makes the skin itchy, red, dry and cracked, but scratching can make it worse, possibly disrupting sleep and causing bleeding and infections.
Honor's skin has now been cleared after she has prescribed methotrexate, a medicine used to treat neck, lung and breast cancers (shown after treatment)
Mrs. Klee, a home care worker for Age UK, added: & # 39; The lack of sleep was the biggest killer.
& # 39; She had broken nights from when she was a baby until she was seven.
& # 39; The sheets were & # 39; covered in blood in the morning from which she had scribbled all night.
& # 39; On some evenings she would scream and beg for me to help her, so I would take a bath at 3 am or take her to distract her from itching.
& # 39; She gets & # 39; still anxiety and stomach ache at night because she associates it with very long, terrible nights where she was awake for hours. & # 39;
Her mother Laura Klee (pictured together) signed an honor to participate in a clinical trial at Churchill Hospital in Oxford
Honor, from Witney, Oxfordshire, has been fighting chronic skin disease since she was four weeks old
HOW DOES METHOTREXATE CURE ECZEMA?
The immune system is important in fighting infections, but sometimes it becomes overactive and causes inflammation in the long term.
People with eczema have a reduced skin barrier, which means that their skin is drier, causing natural moisturizing oils to leak out and environmental allergens to penetrate the skin.
This combination ensures that the skin's immune-fighting cells become overactive and cause redness, itching and swelling of the skin.
Methotrexate dampens the activity of these cells of the immune system to reduce the skin inflammation caused by eczema.
In addition to being used to treat eczema, methotrexate has been licensed for many years to treat a number of inflammatory conditions, including psoriasis and rheumatoid arthritis.
Methotrexate is thought to work by preventing cells from sharing the immune system, but it is not entirely clear how it reduces the severity of eczema.
It takes several weeks for methotrexate to accumulate in cells.
Methotrexate cannot cure eczema, but it can significantly improve its severity.
Source: National Eczema Society
Ms. Klee, desperate for her daughter's cure, agreed that Honor would participate in an NHS study at Churchill Hospital in Oxford.
The treatment of severe atopic eczema study (TREAT) compared two drugs – methotrexate and cyclosporin – to see which one best treats severe eczema in children.
Honor participated in the study in April 2017 and received methotrexate, which she continues to use, despite the completion of the trial in January 2018.
The treatment is usually used to treat cancer, but the NHS is looking at how a lower dose can help patients with the skin condition.
The study – concluded in February – was led by King & # 39; s College London and was funded by the National Institute for Health Research.
Now she is encouraging more people to participate in health research after seeing how her daughter's life has improved dramatically.
People with eczema have an overactive immune system, making them more sensitive to irritants, causing inflamed skin.
Mrs. Klee admitted that she was afraid to give her daughter an unknown drug.
She added: & # 39; We had previously received methotrexate, but I rejected it because the thought of something that suppressed her immune system worried me.
& # 39; The fact that it was offered as part of a process meant that it was being followed incredibly well, so I was glad she was in good hands. & # 39;
And after just three months the Honor eczema began to clear up.
Mrs. Klee added: & # 39; Participation in the process has completely changed our lives.
Honor became & # 39; depressed & # 39; after being forced to give up her & # 39; s because of the chronic skin condition (pictured before her treatment)
& # 39; Before it was rare for Honor to sleep through the night, we are now virtually guaranteed a good night's sleep.
& # 39; Her school attendance is the best it has ever been and she goes to all her clubs again.
& # 39; You hear about eczema and know it's not a particularly good condition, but I had no idea it could be life-changing. It can ruin people's lives and affect the lives of their families. & # 39;
Honor added: & # 39; I feel a lot better now and am happy to sleep again. It is sometimes painful when I am scratching, but it is much better and I can live with it now. & # 39;
Mrs. Klee has now started a blog on Facebook with the title & # 39; Living with eczema support forum and blog & # 39; to help fellow parents struggle with the chronic skin condition.
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