Physicians smile on a common antibiotic taken by millions that is linked to a series of extreme deaths and reactions.
Taken by approximately 3 million Americans, trimetoprim-sulfamethoxazole or the name of the BACTRIM brand, it is usually used to treat mild infections in the chest, bacteria and acne.
Emmie Bellucci, 12, from Texas, received two antibiotic courses for the cystic acne, a severe form that causes painful packages deeply in the skin, last year.
A severe reaction caused their lungs to be injured and closed seriously.
It has been hospitalized with five months, depending on a tube in its trachea, a trachastomy, to help it breathe.
Doctors believe that the medicine could trigger an immune response in young patients like Emmie that damages the lung coating, causing respiratory failure.
Experts who investigate the rare complication are now asking for greater research on the long -term damage and tests of BACTRIM to find risk factors before describing the medication.
Dr. Jennifer Goldman, a specialist in pediatric infectious diseases in Children’s Mercy Kansas City, said: ‘These are good drugs, and this is a very rare condition, but it is not commonly known and necessary.
“There is a window of opportunity to avoid serious complications.”
Emmie Bellucci (in the photo here), a 12 -year -old girl from Texas, entered respiratory failure shortly after taking a second dish of the antibiotic botrim for cystic acne

Emmie has been in the hospital for five months recovering from almost fatal complication. “We thought we lost it,” said his father, Frank Bellucci, to CNN
Emmie He told CNN: “All I know is that it is a miracle that I am here.”
Doctors began to investigate the serious side effects of Botrim in 2018 when Zei Uwadia, 16, fell mysteriously ill and had a pulmonary failure.
After The history of Zei was publishedDoctors of the Mercy of the City of Children, Kansas City, where the teenager was being treated, began to receive reports from other adolescent patients who suffered similar symptoms.
All of them, including Zei, had taken Botrim.
Zei died in 2019 at age 17 two weeks after returning home from the hospital.
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Dr. Goldman and Dr. Jenna Miller of Children’s Mercy Kansas City Published a report in 2021 Detailing 14 young children and adults who believe they suffered acute respiratory distress (e -e -) syndrome, which occurs when the liquid accumulates in the lungs, after taking Botrim.
The condition, which affects 200,000 Americans per year, makes it difficult for the lungs to send oxygen to the bloodstream, leading to organic failure.
One in three patients in the report died, and 20 percent had to have lung transplants.
The review led the FDA to add a warning label to Botrim that indicates ‘serious pulmonary adverse reactions’.
While recipes have decreased slightly in the following years, experts say that doctors and patients should be more aware of possible serious risks such as these before the medication is administered.

Botrim, also called trimetopriga-sulfamethoxazole, is prescribed to approximately 3 million Americans for mild infections, acne and bacteria resistant to medications

Zei Uwadia, in the photo here, from Kansas was news in 2018 when he fell mysteriously ill and became ill and entered into respiratory failure after taking Botrim. He died in 2019 at age 17 only two weeks after returning home from the hospital.

It is not clear when Emmie can return home, although he has gained more mobility and took away the respirator support, according to his family’s facebook updates.
Dr. Miller’s research and Dr. Goldman found that all patients in their study with this severe reaction have the same type of genomic human leukocyte antigen marker (HLA), a type of protein that is found in most of their Cells
These markers help the immune system to say which cells belong to the body and which are strange.
In these patients, a specific HLA marker may have caused an immune reaction called diffuse alveolar lesion with late epithelization, which makes the immune system alveoli attack, air bags in the lung lining.
This leads to inflammation, accumulation of fluids in the lungs and pulmonary failure.
It is not clear if Emmie has this genetic marker.
Dr. Goldman told CNN that it is estimated that 20 to 30 percent of us walk we have that genetic marker, so we know it is a first necessary step to develop this reaction, we need to better understand other genetic risks. ”
The team is working on additional research on genetic risk factors and hopes to develop evidence to help doctors identify these risks before prescribing BACTRIM.
Emmie said: “Many could change, many lives just by investigating.”
It is not clear when Emmie can finally return home, although his family has documented his progress on Facebook, which shows him to take away the trachastomy and walking through the hospital.
The Bellucci family is raising money through GOFUNDME For medical expenses.
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