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Tests with mice showed that resveratrol ¿found in the peel of grapes ¿blocked a gene that causes depressive and anxious behavior

Red wine compound opens the door for new treatment for depression and anxiety, because it closes & # 39; enzyme in the brain that is thought to cause the disorders & # 39;

  • Scientists from the University of Buffalo used mice to test the effects of resveratrol
  • The compound – found in the peel of grapes – protected the mice against symptoms
  • Tests revealed that resveratrol blocked an enzyme that caused the behavior
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A composition rich in red wine would pave the way for new treatments for both depression and anxiety, researchers say.

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Tests with mice showed resveratrol – found in the skin of grapes – blocking an enzyme that causes depressive and anxious behavior.

Experts now say that the compound given to the mice in super-potent doses is a & # 39; effective alternative & # 39; can be for existing medicines.

Although red wine contains resveratrol, killing the amount of mice that only drinks would kill you alone.

Tests with mice showed that resveratrol ¿found in the peel of grapes ¿blocked a gene that causes depressive and anxious behavior

Tests with mice showed resveratrol – found in the peel of grapes – blocked a gene that causes depressive and anxious behavior

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Resveratrol has long been touted as an elixir capable of combating many diseases, from cancer to arthritis and even dementia.

Scientists at the University of Buffalo, New York State, used mice to test the effects of resveratrol on depression and anxiety.

They showed signs of anxiety and depression when they were given too much corticosterone, which regulates the body's response to stress.

But phosphodiesterase 4 (PDE4) – an enzyme released by corticosterone – was actually the cause of the behavior, the results revealed.

Further tests showed that the behavior that the mice showed was caused because PDE4 lowered the levels of an important messenger molecule in the body.

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However, Resveratrol appeared to protect the mice against signs of anxiety or depression by inhibiting PDE4.

The & # 39; effects were similar to those of the PDE4 inhibitor rolipram & # 39 ;, wrote lead author. Ying Xu in a study report.

She said: & # 39; Resveratrol can be an effective alternative to drugs for the treatment of patients with depression and anxiety disorders. & # 39;

The study, published in the journal Neuropharmacology, also included Dr. Xiaoxing Yin of Xuzhou Medical University in China.

CAN DRINKING RED WINE WORK?

Mice involved in the study received the equivalent of up to 10 mg of resveratrol per kilogram of body weight.

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For a 70 kg person this would mean that they needed a dose of 700 mg – the equivalent of 350 glasses of red wine, an amount that would kill.

The average glass of red wine contains 2 mg of resveratrol, according to the Linus Pauling Institute at Oregon State University.

Mice involved in the study received the equivalent of up to 10 mg of resveratrol per kilogram of body weight.

For a 70 kg person this would mean that they needed a dose of 700 mg – the equivalent of 350 glasses of red wine, an amount that would kill.

The average glass of red wine contains 2 mg of resveratrol, according to the Linus Pauling Institute at Oregon State University.

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Antidepressants – including well-known brands such as Prozac, Cipramil and Seroxat – have been proven to be an effective way to treat depression.

However, the pills are all aimed at serotonin or noradrenaline in the brain – not by inhibiting enzymes that may play a role, Xu said.

Only a third of patients with depression see their symptoms improve by taking powerful drugs, she wrote in a study report.

Because resveratrol is already used in food supplements, resveratrol is known to be safe. It would therefore not require a safety investigation.

Resveratrol – an antioxidant also found in peanuts – has proven anti-inflammatory properties in various studies.

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It has also been found to lower harmful cholesterol, protect brain function and lower blood pressure.

However, much of the resveratrol research has been done in animals and test tubes with large amounts of the compound.

Most human studies have focused on additional forms of the compound, in super strength concentrations higher than those in wine.

Figures from the Anxiety and Depression Association of America suggest that up to 40 million people are affected by the conditions in the US.

Data from the Mental Health Foundation suggest that about one-fifth of 16-year-olds in the UK show signs of both mental disorders.

DO YOU DRINK TOO MUCH ALCOHOL? THE 10 QUESTIONS THAT DISCLOSE YOUR RISK

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A screening tool that is widely used by medical professionals is the AUDIT (Alcohol Use Disorders Identification Tests). Developed in collaboration with the World Health Organization, the 10-question test is considered the gold standard to help determine if anyone has problems with alcohol abuse.

The test has been reproduced here with the permission of the WHO.

Answer each question and note the corresponding score to complete it.

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YOUR SCORE:

0-7: You are within the sensible drinking range and have a low risk of alcohol-related problems.

About 8: Indicate harmful or hazardous drinking.

8-15: Average risk level. If you drink at your current level, you risk developing problems with your health and life in general, such as work and relationships. Consider cutting back (see below for tips).

16-19: Higher risk of complications from alcohol. Cutting costs yourself can be difficult at this level, because you can depend on it, so you may need professional help from your doctor and / or counselor.

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20 and older: Possible dependence. Your drinking is already causing problems and you could be dependent. You should definitely consider stopping gradually or at least reducing your drinking. You must seek professional help to determine your dependence level and the safest way to remove alcohol.

Severe dependence may require medically assisted withdrawal or detox in a hospital or specialist clinic. This is due to the likelihood of severe withdrawal symptoms of alcohol in the first 48 hours that require specialist treatment.

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