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CDC issues warning that people treated with Paxlovid for Covid may have rebound symptoms

The Centers for Disease Control and Prevention (CDC) is warning that recipients of Pfizer’s Covid antiviral pill Paxlovid may have rebound symptoms after completing a course of the drug.

The agency issued an advisory Tuesday, after reports emerged in recent months that those who received the drug returned to have symptoms after finishing treatment, even after feeling completely healed in some spots.

Paxlovid is believed to be the most effective treatment against the virus and has been a White House favorite in recent months, with President Joe Biden even making it available to all infected people for free.

Clinical trials showed it could reduce the chance of hospitalization or death from infection by 90 percent if taken within days of the first symptoms, although some fear the protection may not last.

The CDC has issued a warning that some recipients of Pfizer's Covid antiviral pill Paxlovid may re-suffer symptoms of the virus after infection (file photo)

The CDC has issued a warning that some recipients of Pfizer’s Covid antiviral pill Paxlovid may re-suffer symptoms of the virus after infection (file photo)

“Paxlovid continues to be recommended for the early-stage treatment of mild to moderate COVID-19 among people at high risk of progression to severe disease,” the CDC wrote in the advisory.

“…A brief return of symptoms may be part of the natural history of SARS-CoV-2 (the virus that causes COVID-19) infection in some people, regardless of Paxlovid treatment and regardless of disease status.” vaccination”.

Experts aren’t sure why this is happening, or what might be causing a seemingly well person to start feeling sick from the same infection.

“We had three cases in the house with the same pattern,” John Donoghue, 71, told the boston globe about the mysterious phenomena of the past month.

‘Symptoms the second time were milder…somehow we felt that Paxlovid did its job. He eliminated the extreme symptoms of the first round and reduced them very quickly in all three cases.’

He reported that he, his wife and his mother, 95, started taking the drug after contracting Covid.

They each began to feel better after using Paxlovid, but even began to test negative, before their symptoms and positive test status returned once again.

The White House widely touted the drug as the best treatment for someone already infected with the virus (file photo)

The White House widely touted the drug as the best treatment for someone already infected with the virus (file photo)

Dr. Paul Sax, an infectious disease expert at Brigham and Women’s Hospital in Boston, told the Globe that he had heard the same thing happened in patients as well.

‘We continue to monitor data from our ongoing clinical studies and real-world evidence. We have not seen any resistance to Paxlovid, and we are very confident in its clinical efficacy,” Pfizer told DailyMail.com when asked for comment.

The arrival of the drug was received with great fanfare among health and pharmacy experts around the world due to the success of its trials.

Received Emergency Use Authorization from the Food and Drug Administration in late 2021.

While the New York City-based company initially had supply issues, hampering the launch early on, there is reportedly a glut of the drug available in the US right now.

“It is important to recognize that the treatments available today for COVID-19 have provided a true game changer in global efforts to stem the devastation of the pandemic,” the company wrote in an email to DailyMail.com in April.

“Our trials and real-world evidence showed that the treatment has the potential to save patients’ lives, reduce the severity of infections, and eliminate up to nine out of 10 hospitalizations.”

1653408512 535 CDC issues warning that people treated with Paxlovid for Covid

1653408513 691 CDC issues warning that people treated with Paxlovid for Covid

Enthusiasm for the drug was so high that President Biden even talked about it in his State of the Union address earlier this year, saying that any American who needed the drug would have access to it.

However, some of the patients who received the drug now report oddities with their infections after taking the drug.

Experts told the Globe that the likely mechanism at play for the Donoghues and others who have experienced similar phenomena can be described as a game of cat and mouse.

“Literally, Paxlovid is the cat, it suppresses the virus, and then when the cat is gone, the mice come out to play,” Dr. Michael Charness, chief of staff for Veterans Affairs in Boston, told the Globe.

“Paxlovid works very well while it’s there, and for many people it can clear the virus in a single phase of infection.”

“But for some people, maybe because it takes a little longer to build up immunity, they can’t get rid of [all the virus] and the Paxlovid is no longer there to help.

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