Cartoonist Mark Knight published the cartoon in News Limited, The Herald Sun.
The cartoon shows Williams in the foreground throwing a tantrum hitting his racket.
But it was the facial features that burned the most.
Kenya-born humanities scholar Kathomi Gatwiri at Southern Cross University said that oversized lips contributed to Williams's dehumanization.
"The grotesque thing was that his body was too exaggerated, his physical attributes, his lips, his buttocks, his thighs, his arms … He does not look human," he said.
"And when you put that in contrast to how Naomi (Osaka) is depicted or the coach in the caricature, you can see that he is a human being, they are presented in a very careful way, not like an animal."
Comparisons have also been made with racist and derogatory cartoons during the American era of Jim Crow, between 1877 and the mid-1960s.
The images used at the time to support racial segregation showed African Americans as "intellectually and culturally inferior to whites," according to the Jim Crow Museum of Racist Memorabilia.
READ MORE: Opinion: The cartoon of Serena Williams is the latest in a long list of harmful cartoons of black women
The Museum of Ferris State University in Michigan exhibits "anti-black cartoons" to promote "racial understanding and healing."
Mark Knight has defended his work, saying that the accusations of racism are exaggerated and that he was using the tools of satire.
"I have not tried to portray her as a kind of ogre character," he said.
"People are seeing things that are simply not there, people say things that are simply not true.
"The cartoon about Serena is about her bad behavior in the day, not about the race."
Dr Gatwiri said the image exploded the stereotypes of the "angry black woman", who showed up in the Jim Crow era.
"I think the point of discord is when you resort to stereotypes, when you resort to damaging narratives to express your point of view," he said.
"If he had attracted the two women equally, then we would not have this discussion."
She points out the work of Mr. Knight playing Nick Kyrgios in a way that does not dehumanize.
"When you compare those two cartoons (one from Serena Williams, the other from Nick Kyrgios), you portray Nick in a very respectable position," said Dr. Gatwiri.
"He is sitting, he is fully clothed, there is no exaggerated exaggeration of his physical bodily features, so he has no stereotype to draw when it comes to drawing Nick Kyrgios."
The author of The Hate Race, Maxine Beneba Clarke, argued that Mr. Knight had other tools to choose from to make his point as an artist.
Ms. Clarke said she did not sympathize with Mark Knight's defense.
"It's a tried and tested method, they print a racist caricature, they expect dissent, then Bolt, etc., they jump on any criticism, with their strange" Freedom of Expression ".
The lawyer and community defender Nyadol Nyuon said that seeing the caricature brought back memories he would rather forget.
"Mark Knight's caricature, especially the lips, reminded me of these racist brochures that I saw circulating online, if you can not see the similarities, you should go to the specsaver," he said in a Twitter post.
Comedy writer Kara Schlegel said that Mr. Knight took too many artistic licenses by exploiting facial features historically used to demean members of certain races.
"I'm going to use my title for once and explain precisely why this Mark Knight caricature is racist, regardless of what the Herald Sun says," he wrote on Twitter.
"Cartoonists usually represent people of color according to these essential features, Jewish people with big noses, Asian people with rabbit teeth, etc. It did not matter what the real human being looked like. stereotype of people of color while erasing their individuality and identity ".
The Herald Sun editor Damon Johnston supported the cartoon in response to criticism on social media.
"A champion tennis player had a mega tantrum on the world stage, and Mark's caricature represented that," he was quoted in The Herald Sun..
"It has nothing to do with gender or race."
Leaders of civil rights in the US UU
Bernice King, the youngest daughter of civil rights leaders Martin Luther King Jr. and Coretta Scott King, asked Mark Knight to do "more good" with his art.
"Art can be a vehicle to illuminate and eradicate racism, misogyny, etc. This does the opposite," he tweeted to the Herald Sun.
"And we can not afford that in this current social climate, please do it better."
The National Association of Black Journalists called the caricature "disgusting on many levels" and "similar to a sambo."
In a statement, the association said that the role of the caricature in this instance was abused.
"The art of editorial caricature is a visual dialogue about the problems of the day, however, this caricature represents grossly inaccurate two women of color at the US Open, one of the greatest stages of professional sports."
Rolling Stone writer Jamil Smith described the performance as a racial insult.
"This is Jim Crow-racist, I've Sambo & # 39; d Serena Williams, I'm a little surprised that @Knightcartoons does not include a watermelon, for those who are not familiar with the story invoked here, read about the raccoon caricature", wrote on Twitter.