Too high? You can calm an extra dose of CBD oil by eliminating an anxiety protein in the brain caused by THC from marijuana
- Researchers gave groups of rats either only THC, the main psychoactive substance in marijuana, or a combination of THC and CBD
- The rats that received THC only had high levels of a protein called ERK, but the rats that received a combination had normal levels
- ERK activates a signal route in the brain that causes increased emotions such as anxiety and paranoia
- This suggests that CBD compensates for these negative emotions
High levels of cannabidiol (CBD) in marijuana can dilute the psychoactive side effects of tetrahydrocannabinol (THC), new research suggests.
In a study in rats, researchers at Vanier College in Montreal, Quebec, Canada discovered that when rodents were given a combination of CBD and THC, they behaved less anxiously than if they received THC alone.
They believe this is because THC causes peaks in levels of a protein called ERK, which disrupts the brains of animals – and humans – to process and deal with negative emotions such as stress and go beyond them.
This in turn leads to increased levels of anxiety and paranoia.
The findings suggest that CBD may lower these levels.
A new study from Vanier College in Canada found that marijuana with a high THC content compared to CBD causes levels of a protein called ERK to worry, leading to increased anxiety (file image)
THC and CBD are both derived from the cannabis plant.
Together they are part of the cannabinoid group of compounds found in hashish, hash oil and most types of marijuana.
THC is the psychoactive substance responsible for the euphoric, & # 39; high & # 39; feeling that is often associated with marijuana.
The connection works with CB1 receptors in the central nervous system and the brain and creates the feeling of euphoria and anxiety.
But CBD, which is non-psychoactive, does not fit well with these receptors and is thought to be responsible for some therapeutic effects of marijuana, such as pain relief.
Previous research has shown that pot strains with a high THC and CBD content have increased side effects such as paranoia and anxiety.
However, the biological mechanism behind this process was not understood.
For the new study, published in the journal JNeurosci, the team split rats into three groups.
The first group received only THC, the second received a combination of THC and CBD and the third group received neither.
Researchers discovered that the rodents that only received THC had higher than normal levels of a protein called ERK and were more anxious.
But the rats that received both CBD and THC behaved in the same way as the control rats; both groups had normal levels of ERK and had less anxious behavior.
Based on these results, the researchers believe that THC activates ERK, while CBD inhibits it.
a study discovered that ER visits related to marijuana in Colorado increased by at least fourfold after marijuana was legalized.
In 2012, doctors at the UCHealth University of Colorado Hospital saw about one patient with a marijuana-related problem every other day.
In 2016, doctors saw two to three such patients a day.
Patients often came in with conditions such as racing hearts – which can have an effect of increasing THC levels of anxiety.
Recreational marijuana is legal in 11 states and Washington, DC, and 33 states and DC have legalized medical marijuana.
A poll by the Pew Research Center in 2018 showed that 62 percent of Americans support marijuana legalization, double the number two decades ago in 2000.
Opinions on legalization differ per political party, with 69 percent of the democrats supporting it, compared to 75 percent of the independents and only 45 percent of the republicans.
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