Can not quit smoking? The intense psychedelic experiences triggered by magic mushrooms could help

The use of psychoactive drugs, such as magic mushrooms, could help people overcome their addiction to smoking, as suggested by scientists (stock image)

According to scientists, the use of psychoactive drugs, such as magic mushrooms, could help people overcome their tobacco addiction.

This is because intense psychedelic experiences mean that they forget withdrawal symptoms, scientists say.

The active compound found in magic mushrooms is called psilocybin and was administered to a handful of smokers.

The six-year study aimed to discover the mechanism in the brain that makes it so difficult to quit.

The use of psychoactive drugs, such as magic mushrooms, could help people overcome their addiction to smoking, as suggested by scientists (stock image)

The use of psychoactive drugs, such as magic mushrooms, could help people overcome their addiction to smoking, as suggested by scientists (stock image)

"Smoking cigarettes today is a huge public health scourge and there are no effective and reliable treatments," said Tehseen Noorani of the Bloomberg Public Health School at Johns Hopkins University and Durham University.

"An open-label pilot study had impressive results in the treatment of smoking addiction with psilocybin-assisted psychotherapy, and we wanted to better understand how it worked, commonly known as the 'mechanisms of change'."

For the study, the researchers interviewed 12 people who had participated in a previous study on cessation of smoking facilitated by psilocybin.

In the original study, participants received cognitive behavior therapy along with two or three sessions of psilocybin treatment.

Interviews were conducted an average of 30 months after the initial psilocybin sessions.

Nine of the 15 participants had stopped smoking effectively after treatment with the compound derived from magic mushrooms, while two relapsed and one participant became a social smoker.

Participants also reported benefits in addition to overcoming nicotine addiction.

The people in the study reported high levels of aesthetic appreciation, openness to experience and commitment in the community.

"The careful preparation of the participants and the facilitation of the sessions was vital, as was the trust in the team and the relationship, so that the participants could explore their addiction to tobacco and relax completely in their experiences of psilocybin," he said. Dr. Noorani.

The six-year study aimed to discover the mechanism in the brain that makes it hard to kick the habit (stock image)

The six-year study aimed to discover the mechanism in the brain that makes it hard to kick the habit (stock image)

The six-year study aimed to discover the mechanism in the brain that makes it hard to kick the habit (stock image)

"The way in which the protocol was formulated seemed to work well to dislodge tobacco addiction.

"Participants reported how deep psychedelic experiences were for days after, displacing withdrawal symptoms, such as cravings during this time period."

The research is published in the Journal of Psychopharmacology.

In May, researchers revealed that magical mushrooms can also improve emotional processing in depressed patients.

A study of 17 patients with treatment-resistant depression, published in Psychopharmacology, found that treatment with psilocybin along with psychological support was associated with better recognition of emotional faces.

The researchers showed patients static color photographs of six male actors and six white women who transformed to create six dynamic emotional stimuli that express happiness, neutrality, sadness, anger, disgust or fear.

The patients who received the treatment were better able to categorize the faces that show the emotions.

The study also gave a placebo treatment to 16 people. They did not show any improvement.

"Before treatment with psilocybin, depressed patients in this trial showed a global deficit in the processing of emotional faces compared to healthy controls, as reflected in longer reaction times to identify all types of emotions," they explained. the researchers.

"We observed an improvement in reaction time after treatment for all types of emotions in depressed patients."

DO THE SCIENTISTS WITHOUT DEVELOPMENT HAVE THE RECIPE & # 39; DE & # 39; MAGIC SHROOMS & # 39 ;?

Research in recent decades has suggested that compound psilocybin can have a number of therapeutic benefits, with potential to help treat anxiety, depression and even addiction.

But until now, the & # 39; recipe & # 39; for psilocybin remains a mystery.

In a new study, scientists have characterized the four enzymes that fungi use to make this compound for the first time, setting the stage for the pharmaceutical production of the "powerful psychedelic fungal drug."

Scientists have characterized the four enzymes that fungi use to make psilocybin

Scientists have characterized the four enzymes that fungi use to make psilocybin

Scientists have characterized the four enzymes that fungi use to make psilocybin

After identifying and characterizing the enzymes behind psilocybin, the team from Friedrich Schiller University in Jena was able to develop the first enzymatic synthesis of the compound, reports C & EN, a publication of the American Chemical Society.

To arrive at the correct "recipe", the team in the new study sequenced the genomes of two fungi species.

Then, they used bacteria and fungi designed to confirm the activity of the genes and the order of the synthetic steps, according to C & EN.

Their efforts revealed a new enzyme, called PsiD strips of carbon dioxide tryptophan, while another adds a hydroxyl group – or, oxygen and hydrogen.

Another enzyme, known as PsiK, acts as a catalyst for phosphotransfer.

Then, an enzyme known as PsiM catalyzes the transfer of methyl groups.

Based on their discovery, the researchers developed a "single-vessel reaction" to create psilocybin from 4-hydroxy-L-tryptophan, using three of the enzymes: PsiD, PsiK and PsiM.

According to the team, the results could now "lay the foundations" for the production of drugs based on psychedelic fungi.

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