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Being fat causes a ‘troublesome’ immune response to Covid-19, scientists fear as SAGE investigates

Being fat causes a ‘troublesome’ immune response to COVID-19, scientists fear, as the government’s SAGE committee is investigating why obesity increases the risk of death.

Scientists who advise ministers are investigating possible underlying mechanisms that cause serious illness in obese people.

According to data from intensive care units, people of healthy weight are a minority of critically ill COVID-19 patients. Almost three quarters carry extra weight.

And NHS hospital data this week revealed that obesity increases the risk of coronavirus death by nearly 40 percent.

While the reasons remain unclear, scientists have warned about a potentially dysfunctional immune system that makes fighting the virus more difficult.

Fat cells – more of which are in the tissues of obese people – can contain vital immune cells, which reduces their availability in the body.

Or it could swing the other way – the immune response could become overdrive, known as a cytokine storm, thought to play an important role in COVID-19 death.

There is no data to indicate that obese people are more likely to contract the deadly virus in the first place.

Being fat causes a 'tricky' immune response to COVID-19, scientists fear, as government SAGE committee investigates why obesity increases risk of death

Being fat causes a ‘tricky’ immune response to COVID-19, scientists fear, as government SAGE committee investigates why obesity increases risk of death

According to the ICNARC report, people of healthy weight are a minority of the critically ill COVID-19 patients. Almost three quarters have extra weight (BMI from 25 to 40+)

According to the ICNARC report, people of healthy weight are a minority of the critically ill COVID-19 patients. Almost three quarters have extra weight (BMI from 25 to 40+)

According to the ICNARC report, people of healthy weight are a minority of the critically ill COVID-19 patients. Almost three quarters have extra weight (BMI from 25 to 40+)

The times reports that the SAGE committee will investigate the relationship between obesity and severe COVID-19 disease.

With the virus death toll in the UK exceeding 28,000, data sets from NHS hospitals have revealed the most at-risk patients.

It includes people who are obese, those with underlying health problems, and those with a BAME background. Men also represent more than 70 percent of the patients.

According to the National Audit and Research Center of the Intensive Care Unit, which collects data from NHS hospitals, there is a higher percentage of people who are obese in intensive care units than in the general population.

The figures, released on Friday, are based on a sample of 7,542 critically ill patients confirmed to have Covid-19.

According to the ICNARC reportpeople of healthy weight are a minority of the critically ill COVID-19 patients.

Nearly three-quarters (73 percent) carry extra weight.

About 35 percent have a BMI between 25 and 30, which the NHS considers “overweight,” 31 percent are obese, and just over seven percent are severely obese.

By comparison, in the general population of England, 64.3 percent of adults are either overweight (35.6 percent) or obese (28.7 percent), Government data from 2019 shows.

There are more morbidly obese people in intensive care (7.32) than among the population (3.6 percent in England).

Dr. Dyan Sellayah, professor of cellular and organismal metabolism, University of Reading, said, “What we know from the data so far is that obesity is a clear risk factor for serious diseases.

Why are obese people more at risk of becoming very ill from COVID-19?

Studies have shown that obese people are more likely to have serious complications or die from infections, such as the flu.

Doctors say fat people’s immune systems are constantly boosted as they try to protect and repair the damage inflammation causes to cells.

Using all its energy to ward off inflammation means it The body’s defense system has few means to defend itself against a new infection such as COVID-19.

Dr. Dyan Sellayah, a professor of cellular and organism metabolism, University of Reading, said obese people tend to have a dysfunctional immune system.

“Their fat tissue, for example, becomes a reservoir for immune cells called macrophages. Although these cells are in our fat under normal conditions, they are more common in obesity and more difficult (they begin to secrete inflammatory cytokines) and negatively affect immune and metabolic health. ‘

Obese people may eat a diet low in fiber and antioxidants – which help keep the immune system healthy – such as fruits and vegetables.

Most patients with a BMI over 40 suffer from respiratory problems ranging from simple shortness of breath to a potentially life-threatening condition known as obesity hypoventilation syndrome (OHS).

Being overweight also makes it more difficult for the diaphragm and lungs to expand and breathe in oxygen. Starved of oxygen, organs will begin to fail.

These factors may explain why the lungs of obese people tend to fail more quickly when the new coronavirus strikes, compared to a healthy person.

COVID-19 kills by spreading deep into the lungs and causing complications such as pneumonia.

There are several other factors that can increase the chance of becoming seriously ill with coronavirus, including a lack of exercise.

Studies have shown that physical activity increases the number of certain immune cells that help boost immune activity.

Clogged blood vessels also make it difficult for blood-bearing immune cells to pass and repair cells throughout the body.

Obese people often have a dysfunctional immune system – their adipose tissue, for example, becomes a reservoir for immune cells known as macrophages.

Although these cells are in our fat under normal conditions, they are more common in obesity and more difficult (they begin to secrete inflammatory cytokines) and negatively affect immune and metabolic health.

“It is likely, therefore, that the immune response to the virus is not effective in obese people, which may explain why people with a BAME background with a higher incidence of obesity are vulnerable to the virus.”

Studies have shown that obese people are more likely to develop serious complications or die from infections, such as the flu, because their immune systems are constantly boosted while trying to protect and repair the damage that inflammation causes to cells.

By using all its energy to ward off inflammation, the body’s defense system has very little resources to defend itself against a new infection such as COVID-19.

Obesity is one of the major risk factors for comorbidities, including heart disease, diabetes and high blood pressure, all of which have been identified as common medical conditions in COVID-19 patients.

People with underlying health problems are more vulnerable to serious illnesses from the virus.

Research published this week, considered the largest of its kind in Europe, found that more than half (53 percent) of the COVID-19 patients in the UK had at least one comorbidity.

Nearly a third (29 percent) suffered from heart disease – conditions that block blood vessels and make it difficult to pump blood and oxygen around the body.

Nearly a fifth (19 percent) had diabetes, the same number had lung disease, 15 percent had kidney disease, and 14 percent were asthmatic.

The same report found that once in the hospital, survival rates may be lower in obese people.

The analysis of 17,000 COVID-19 admissions found that mortality rates were 37 percent higher in obese patients, second only to dementia (39 percent) but more than heart disease (31 percent).

The study was conducted by a team of the top UK infectious disease scientists who are part of the global pandemic planning agency.

Researchers who analyzed nearly 17,000 COVID-19 admissions showed that obesity increases the risk of coronavirus death by nearly 40 percent. More than half (53 percent) of hospitalized patients had at least one comorbidity (shown). The most common were heart disease (29 percent), diabetes (19 percent), lung disease (19 percent), kidney disease (15 percent), and asthma (14 percent)

Researchers who analyzed nearly 17,000 COVID-19 admissions showed that obesity increases the risk of coronavirus death by nearly 40 percent. More than half (53 percent) of hospitalized patients had at least one comorbidity (shown). The most common were heart disease (29 percent), diabetes (19 percent), lung disease (19 percent), kidney disease (15 percent), and asthma (14 percent)

Researchers who analyzed nearly 17,000 COVID-19 admissions showed that obesity increases the risk of coronavirus death by nearly 40 percent. More than half (53 percent) of hospitalized patients had at least one comorbidity (shown). The most common were heart disease (29 percent), diabetes (19 percent), lung disease (19 percent), kidney disease (15 percent), and asthma (14 percent)

BORIS WAS BADLY AFFECTED BY CORONAVIRUS ‘BECAUSE HE WAS TOO HEAVY’

A British NHS physician today claimed that Prime Minister Boris Johnson was hit so hard by the coronavirus because he is “significantly” overweight.

Consultant cardiologist Dr. Aseem Malhotra said there is a tenfold risk of death from the disease – which has killed more than 20,000 Britons so far – if patients are obese.

He pointed out that other “leaner” cabinet members – such as health secretary Matt Hancock – recovered much faster and were not hospitalized.

Other top officials and consultants who have recovered from the virus include Chief Medical Officer Chris Whitty, Chief Adviser Dominic Cummings and Health Minister Nadine Dorries.

55-year-old Johnson had been struggling with his weight for a long time and revealed in 2018 that he weighed nearly 16 and a half stones, putting him at 5ft 9in in the high risk category.

Dr. Malhotra said: Clearly, it was very worrying for the entire country to see our Prime Minister hospitalized with COVID-19.

“Now it is an observation, but it fits the evidence, unfortunately Boris is very overweight.

“I spoke to one of his senior advisors a few years ago when he was Mayor of London, who personally concerned me about his weight.

‘Overweight people also seem to be spreading the virus much longer and are also clearly getting sicker.

“If you notice Chris Whitty, Matt Hancock and other cabinet members who got the virus have not understood it all that much and are essentially skinny.

“They don’t seem to be affected by it as he was.”

Impaired lung function and inflamed tissue under the skin and around internal organs may be associated with the increased risk, the team says.

They found that both factors can cause a life-threatening overreaction of the body’s immune response that can harm patients.

Cytokines are chemical signaling molecules that direct a healthy immune response. They tell immune cells to attack viral molecules in the body.

But in some people, this reaction goes overdrive, and immune cells also begin to attack healthy tissue, known as a cytokine storm.

Fredrik Karpe, a professor of metabolic medicine at Oxford University, said that if you have ‘a big belly’, it can be problematic when lying down.

The weight of stomach fat pushes the diaphragm up, decreasing lung volume.

COVID-19 is a respiratory disease that affects lung function in severe cases. Therefore, limited lung capacity would make symptoms worse.

If lung function has already deteriorated, there is not enough oxygen in the blood that can affect vital organs, such as the heart.

Dr. Sellayah also explained that people with extra weight have more cells that need oxygen to work, further reducing the amount available to organs.

He said, “As your infection progresses and the virus infects more and more cells, the demand for oxygen in the tissues is much greater for an obese person than for a slim person.

“Ultimately, the obese body is overwhelmed by the lack of oxygen coming to the major organs.”

As the country is gripped by the coronavirus crisis, being overweight and its associated health risks are highlighted as never before.

Last week, a British NHS doctor today claimed that Prime Minister Boris Johnson was so badly affected by the corona virus because he is “significantly” overweight.

Consultant cardiologist Dr. Aseem Malhotra said there is a tenfold risk of death from the disease – which has killed more than 20,000 Britons so far – if patients are obese.

He pointed out that other “leaner” cabinet members – such as health secretary Matt Hancock – recovered much faster and were not hospitalized.

Other top officials and consultants who have recovered from the virus include Chief Medical Officer Chris Whitty, Chief Adviser Dominic Cummings and Health Minister Nadine Dorries.

55-year-old Johnson had been struggling with his weight for a long time and revealed in 2018 that he weighed nearly 16 and a half stones, putting him at 5ft 9in in the high risk category.

Dr. Malhotra said: Clearly, it was very worrying for the entire country to see our Prime Minister hospitalized with COVID-19.

“Now it is an observation, but it fits the evidence, unfortunately Boris is very overweight.

“I spoke to one of his senior advisors a few years ago when he was Mayor of London, who personally concerned me about his weight.”

So far, there is no evidence to suggest that obese people are more likely to contract the virus in the first place.

However, some scientists have said now is a good time to try to lose weight in the face of the pandemic.

Professor Neil Ferguson, an epidemiologist at Imperial College who advises the government, told The Sunday Times, “It’s always better to stay fit and healthy.

“We need to assess our risks from a personal perspective, including getting fit and losing weight.”

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